Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328569
Type: Artigo
Title: Xpd C.934g > A Polymorphism Of Nucleotide Excision Repair Pathway In Outcome Of Head And Neck Squamous Cell Carcinoma Patients Treated With Cisplatin Chemoradiation
Author: Lopes-Aguiar
Leisa; Dias Costa
Ericka Francislaine; Silva Nogueira
Guilherme Augusto; Penna Lima
Tathiane Regine; Visacri
Marilia Berlofa; Pincinato
Eder Carvalho; Calonga
Luciane; Mariano
Fernanda Viviane; de Almeida Milani Altemani
Albina Messias; Carrasco Altemani
Joao Maurcio; Coutinho-Camillo
Claudia Malheiros; Fernandes Ribeiro Alves
Maria Almerinda Vieira; Moriel
Patricia; Ramos
Celso Dario; Chone
Carlos Takahiro; Passos Lima
Carmen Silvia
Abstract: This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation. Patients with XPC c.2815AC or CC and XPD c.934GA or AA genotypes had 0.20 and 0.38 less chances of presenting moderate/severe ototoxicity and nausea, respectively. Patients with XPD c.934AA and c.2251AC or CC genotypes had 8.64, 12.29 and 3.55 more chances of achieving complete response (CR), consistent ototoxicity and nephrotoxicity, respectively. AA haplotype of XPD and ACT haplotype of XPD and ERCC1 SNPs were associated with 9.30 and 3.41 more chances of achieving CR and consistent nephrotoxicity, respectively. At 24 months of follow-up, patients with XPD c.934AA genotype presented lower progression-free survival and overall survival in Kaplan-Meier estimates, and differences between groups remained the same in univariate Cox analysis. Patients with XPD c.934AA genotype had 2.13 and 2.04 more risks of presenting tumor progression and death than others in multivariate Cox analysis. Our data present preliminary evidence that XPC c.2815A>C, XPD c.934G>A and c.2251A>C, and ERCC1 c.354C>T SNPs alter outcome of HNSCC patients treated with CDDP chemoradiation.
Subject: Head And Neck Squamous Cell Carcinoma
Cisplatin
Nucleotide Excision Repair Pathway
Single Nucleotide Polymorphisms
Outcome
Editor: Impact Journals Llc
Orchard Park
Citation: Oncotarget. Impact Journals Llc, v. 8, p. 16190 - 16201, 2017.
Rights: aberto
Identifier DOI: 10.18632/oncotarget.7668
Address: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=7668&pubmed-linkout=1
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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