Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328387
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremailpavargas@fop.unicamp.brpt_BR
dc.typeArtigopt_BR
dc.titleBpi-fold (bpif) Containing/plunc Protein Expression In Human Fetal Major And Minor Salivary Glandsen
dc.contributor.authorMoreira Alvespt_BR
dc.contributor.authorDaniel Berretta; Binglept_BR
dc.contributor.authorLynne; Binglept_BR
dc.contributor.authorColin David; Lourencopt_BR
dc.contributor.authorSilvia Vanessa; Silvapt_BR
dc.contributor.authorAndreia Aparecida; Pereirapt_BR
dc.contributor.authorDebora Lima; Vargaspt_BR
dc.contributor.authorPablo Agustinpt_BR
unicamp.authorVargas, Pablo Agustin] Univ Estadual Campinas Unicamp, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP, Brazilpt_BR
unicamp.author.external[Moreira Alves, Daniel Berrettapt_BR
unicamp.author.externalSilva, Andreia Aparecidapt_BR
unicamp.author.externalPereira, Debora Limapt_BR
unicamp.author.external[Bingle, Lynne] Univ Sheffield, Sch Clin Dent, Acad Unit Oral & Maxillofacial Pathol, Sheffield, S Yorkshire, Englandpt_BR
unicamp.author.external[Bingle, Colin David] Univ Sheffield, Sch Med, Royal Hallamshire Hosp, Acad Unit Resp Med, Sheffield, S Yorkshire, Englandpt_BR
unicamp.author.external[Lourenco, Silvia Vanessa] Univ Sao Paulo, Sch Dent, Dept Gen Pathol, Sao Paulo, SP, Brazilpt_BR
dc.subjectImmunityen
dc.subjectInnateen
dc.subjectImmunohistochemistryen
dc.subjectHumansen
dc.subjectSalivary Glandsen
dc.description.abstractThe aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second trimester and thus gain further insight into the function of these proteins. Early fetal heads, and major and minor salivary glands were collected retrospectively and glands were classified according to morphodifferentiation stage. Expression of BPI-fold containing proteins was localized through immunohistochemistry. BPIFA2, the major BPI-fold containing protein in adult salivary glands, was detected only in the laryngeal pharynx; the lack of staining in salivary glands suggested salivary expression is either very late in development or is only in adult tissues. Early expression of BPIFA1 was seen in the trachea and nasal cavity with salivary gland expression only seen in late morphodifferentiation stages. BPIFB1 was seen in early neural tissue and at later stages in submandibular and sublingual glands. BPIFA1 is significantly expressed in early fetal oral tissue but BPIFB1 has extremely limited expression and the major salivary BPIF protein (BPIFA2) is not produced in fetal development. Further studies, with more sensitive techniques, will confirm the expression pattern and enable a better understanding of embryonic BPIF protein function.en
dc.relation.ispartofBrazilian Oral Researchpt_BR
dc.publisherSociedade Brasileira de Pesquisa Odontologicapt_BR
dc.publisherSão Paulopt_BR
dc.date.issued2017pt_BR
dc.identifier.citationBrazilian Oral Research. Sociedade Brasileira De Pesquisa Odontologica, v. 31, p. , 2017.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume31pt_BR
dc.rightsabertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1806-8324pt_BR
dc.identifier.eissn1678-8079pt_BR
dc.identifier.wosidWOS:000396564700005pt_BR
dc.identifier.doi10.1590/1807-3107BOR-2017.vol31.0006pt_BR
dc.identifier.urlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242017000100207&lng=en&tlng=enpt_BR
dc.description.sponsorshipNational Council for Scientific and Technological Development [Cnpq 305967/2014-2, Cnpq PVE 400039/2014-1]pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2017-11-13T13:24:52Z-
dc.date.accessioned2017-11-13T13:24:52Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:24:52Z (GMT). No. of bitstreams: 1 000396564700005.pdf: 1488934 bytes, checksum: 9cd07747640285af9efaf41f17748400 (MD5) Previous issue date: 2017en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328387-
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