Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328387
Type: Artigo
Title: Bpi-fold (bpif) Containing/plunc Protein Expression In Human Fetal Major And Minor Salivary Glands
Author: Moreira Alves
Daniel Berretta; Bingle
Lynne; Bingle
Colin David; Lourenco
Silvia Vanessa; Silva
Andreia Aparecida; Pereira
Debora Lima; Vargas
Pablo Agustin
Abstract: The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second trimester and thus gain further insight into the function of these proteins. Early fetal heads, and major and minor salivary glands were collected retrospectively and glands were classified according to morphodifferentiation stage. Expression of BPI-fold containing proteins was localized through immunohistochemistry. BPIFA2, the major BPI-fold containing protein in adult salivary glands, was detected only in the laryngeal pharynx; the lack of staining in salivary glands suggested salivary expression is either very late in development or is only in adult tissues. Early expression of BPIFA1 was seen in the trachea and nasal cavity with salivary gland expression only seen in late morphodifferentiation stages. BPIFB1 was seen in early neural tissue and at later stages in submandibular and sublingual glands. BPIFA1 is significantly expressed in early fetal oral tissue but BPIFB1 has extremely limited expression and the major salivary BPIF protein (BPIFA2) is not produced in fetal development. Further studies, with more sensitive techniques, will confirm the expression pattern and enable a better understanding of embryonic BPIF protein function.
Subject: Immunity
Innate
Immunohistochemistry
Humans
Salivary Glands
Editor: Sociedade Brasileira de Pesquisa Odontologica
São Paulo
Citation: Brazilian Oral Research. Sociedade Brasileira De Pesquisa Odontologica, v. 31, p. , 2017.
Rights: aberto
Identifier DOI: 10.1590/1807-3107BOR-2017.vol31.0006
Address: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242017000100207&lng=en&tlng=en
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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