Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328114
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremailmariacristina.arci@gmail.compt_BR
dc.typeArtigopt_BR
dc.titleDoes Side Of Onset Influence The Pattern Of Cerebral Atrophy In Parkinson's Disease?en
dc.contributor.authorSantospt_BR
dc.contributor.authorMaria C. A.; Campospt_BR
dc.contributor.authorLidiane S.; Guimaraespt_BR
dc.contributor.authorRachel P.; Piccininpt_BR
dc.contributor.authorCamila C.; Azevedopt_BR
dc.contributor.authorPaula C.; Piovesanapt_BR
dc.contributor.authorLuiza G.; De Campospt_BR
dc.contributor.authorBrunno Machado; Scarparo Amato-Filhopt_BR
dc.contributor.authorAugusto C.; Cendespt_BR
dc.contributor.authorFernando; D'Abreupt_BR
dc.contributor.authorAnelyssapt_BR
unicamp.authorD'Abreu, Anelyssa] State Univ Campinas UNICAMP, Dept Neurol, Neuroimaging Lab, Sao Paulo, Brazilpt_BR
unicamp.author[Scarparo Amato-Filho, Augusto C.] State Univ Campinas UNICAMP, Dept Radiol, Sao Paulo, Brazilpt_BR
unicamp.author.external[Santos, Maria C. A.pt_BR
unicamp.author.externalCampos, Lidiane S.pt_BR
unicamp.author.externalGuimaraes, Rachel P.pt_BR
unicamp.author.externalPiccinin, Camila C.pt_BR
unicamp.author.externalAzevedo, Paula C.pt_BR
unicamp.author.externalPiovesana, Luiza G.pt_BR
unicamp.author.externalDe Campos, Brunno Machadopt_BR
unicamp.author.externalCendes, Fernandopt_BR
dc.subjectParkinson's Diseaseen
dc.subjectGray Matter Atrophyen
dc.subjectLateralityen
dc.subjectVoxel-based Morphometryen
dc.subjectNeuroimagingen
dc.description.abstractImaging studies have revealed widespread neurodegeneration in Parkinson's disease (PD), but only a few considered the issue of asymmetrical clinical presentations. Objective: To investigate if the side of onset influences the pattern of gray matter (GM) atrophy in PD. Methods: Sixty patients (57.87 +/- 10.27 years) diagnosed with idiopathic PD according to the U.K. Brain Bank criteria, 26 with right-sided disease onset (RDO) and 34 with left-sided disease onset (LDO), were compared to 80 healthy controls (HC) (57.1 +/- 9.47 years). We acquired T1-weighted images on a 3 T scanner. Images were processed and analyzed with VBM8 (SPM8/Dartel) on Matlab R2012b platform. Statistic assessments included a two-sample test (family-wise error p < 0.05) with extent threshold of 20 voxels. Results: Compared to HC, LDO patients had GM atrophy in the insula, putamen, anterior cingulate, frontotemporal cortex, and right caudate, while the RDO group showed atrophy at the anterior cingulate, insula, frontotemporal, and occipital cortex. Conclusion: This study revealed widespread GM atrophy in PD, predominantly in the left hemisphere, regardless of the side of onset. Future investigations should also consider handedness and side of onset to better characterize cerebral involvement and its progression in PD.en
dc.relation.ispartofFrontiers in Neurologypt_BR
dc.publisherFrontiers Media SApt_BR
dc.publisherLausannept_BR
dc.date.issued2016pt_BR
dc.date.monthofcirculationsetpt_BR
dc.identifier.citationFrontiers In Neurology. Frontiers Media Sa, v. 7, p. , 2016.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume7pt_BR
dc.rightsabertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1664-2295pt_BR
dc.identifier.wosidWOS:000383013600001pt_BR
dc.identifier.doi10.3389/fneur.2016.00145pt_BR
dc.identifier.urlhttp://journal.frontiersin.org/article/10.3389/fneur.2016.00145/fullpt_BR
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/05286-7]pt_BR
dc.description.sponsorshipCNPq [74873/2010-2]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2017-11-13T13:23:30Z-
dc.date.accessioned2017-11-13T13:23:30Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:23:30Z (GMT). No. of bitstreams: 1 000383013600001.pdf: 1189920 bytes, checksum: 451b28bef828ecb663904184344ecdcc (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328114-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000383013600001.pdf1.16 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.