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Type: Artigo
Title: Low-density Lipoprotein Cholesterol Is Associated With Asymptomatic Sensorineural Hearing Loss In Patients With Systemic Lupus Erythematosus
Author: Ferrari
Ana Luisa V.; Calonga
L.; Lapa
Aline T.; Postal
Mariana; Sinicato
Nailu A.; Pelicari
Karina O.; Peres
Fernando A.; Valente
Joao Paulo; Soki
Marcelo; Appenzeller
Simone; Costallat
Lilian T. L.
Abstract: The aims of this study were to determine the frequency of asymptomatic sensorineural hearing loss (SNHL) in systemic lupus erythematosus (SLE) and to determine the association between SNHL and demographic, clinical, and laboratory features and cardiovascular risk factors. Methods We conducted a cross-sectional study including consecutive female SLE patients. We performed audiometry and clinical and laboratory evaluation and determined cardiovascular risk factors in all patients. Statistical analysis included principal component analysis and logistic regression. Results Eighty-nine women were included with mean age of 38.98 (SD, 7.77) years and mean disease duration of 10.29 (SD, 9.19) years. Asymptomatic SNHL was observed in 14 patients (16%). In logistic regression model, only low-density lipoprotein levels (z = 2.64; P = 0.008) were associated with SNHL. Conclusions We observed asymptomatic SNHL in 16% of SLE and an association with low-density lipoprotein levels suggesting atherosclerosis as a mechanism. Follow-up is needed to determine clinical implications.
Subject: Low-density Lipoprotein Cholesterol
Sensorineural Hearing Loss
Systemic Lupus Erythematosus
Editor: Lippincott Williams & Wilkins
Citation: Jcr- Journal Of Clinical Rheumatology. Lippincott Williams & Wilkins, v. 22, p. 312 - 315, 2016.
Rights: fechado
Identifier DOI: 10.1097/RHU.0000000000000382
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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