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Type: Artigo
Title: Diagnostic Accuracy Of Serum Biomarkers For Head And Neck Cancer: A Systematic Review And Meta-analysis
Author: Silva Guerra
Eliete Neves; Rego
Daniela Fortunato; Elias
Silvia Taveira; Coletta
Ricardo D.; Mendonca Mezzomo
Luis Andre; Gozal
David; Canto
Graziela De Luca
Abstract: Serum biomarkers could be helpful to characterize head and neck squamous cell carcinoma (HNSCC). Thus, the purpose of this systematic review and meta-analysis was to determine the diagnostic capability of serum biomarkers in the assessment of HNSCC patients. Studies were gathered by searching LILACS, PubMed, Science Direct, Scopus and Web of Science up to April 10th, 2015. Studies that focused on serum biomarkers in the diagnosis of HNSCC compared with controls were considered. Sixty-five studies were identified, and the sample size included 9098 subjects. Combined biomarkers demonstrated improved accuracy than those tested individually. Therefore, 12.8% of single and 34.3% of combined indicated that serum biomarkers discriminate patients with HNSCC from controls. The combined biomarkers with better diagnostic capability included Epidermal growth factor receptor (EGFR) + Cyclin D1 and squamous cell cancer-associated antigen (SCCA) + EGFR + Cyclin D1. Beta(2)-microglobin may also be a promising single biomarker for future studies. Serum biomarkers can be potentially useful in the diagnosis of HNSCC. However, further research is required to validate these biomarkers. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Subject: Biological Markers
Head And Neck Cancer
Systematic Review
Editor: Elsevier Science Inc
New York
Citation: Critical Reviews In Oncology/hematology. Elsevier Science Inc, v. 101, p. 93 - 118, 2016.
Rights: fechado
Identifier DOI: 10.1016/j.critrevonc.2016.03.002
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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