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Type: Artigo
Title: Sensitive Electroanalytical Detection On Gce: The Case Of Lipoic Acid And Its Interaction With N-acetylcysteine And Glutathione
Author: Santos
Ana Caroline F.; Moura
Fabiana A.; Tanaka
Auro A.; Luz
Rita C. S.; Damos
Flavio S.; Kubota
Lauro T.; Goulart
Marilia O. F.
Abstract: A simple and sensitive electrochemical method was developed for the determination of N-Acetylcysteine (NAC) and Glutathione (GSH), on glassy carbon electrode. The results indicate that -lipoic acid (LipS(2)) is oxidized at the electrode, but is regenerated by thiols, suggesting a redox catalytic effect. Under optimized conditions, the analytical curves for NAC and GSH were obtained in the range of 1 up to 10 mu M and 1 up to 60 mu M, respectively. The quantification can be performed in a single assay with high sensitivity, reproducibility and low detection limit of 0.27 and 0.67 mu M for NAC and GSH, respectively. This method was successfully applied to the determination of NAC and GSH in artificial saliva and human urine samples, with excellent recovery results.
Subject: Glutathione
Lipoic Acid
Voltametric Determination
Editor: Wiley-V C H Verlag GMBH
Citation: Electroanalysis. Wiley-v C H Verlag Gmbh, v. 28, p. 2818 - 2826, 2016.
Rights: fechado
Identifier DOI: 10.1002/elan.201600205
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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