Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/320122
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbn1532-2823pt
dc.contributor.authorunicampMacedo, Cristina Gomes dept_BR
dc.contributor.authorunicampRocha Neto, Luiz Marques dapt_BR
dc.contributor.authorunicampAbdalla, Henrique Ballassinipt_BR
dc.contributor.authorunicampClemente-Napimoga, Juliana Trindadept_BR
dc.typeArtigopt_BR
dc.titleThe role of endogenous opioid peptides in the antinociceptive effect of 15-deoxy (delta 12,14)-prostaglandin J(2) in the temporomandibular jointpt_BR
dc.contributor.authorMacedo, C. G.pt_BR
dc.contributor.authorNapimoga, M. H.pt_BR
dc.contributor.authorRocha-Neto, L. M.pt_BR
dc.contributor.authorAbdalla, H. B.pt_BR
dc.contributor.authorClemente-Napimoga, J. T.pt_BR
unicamp.author.emailjuliana.napimoga@fop.unicamp.brpt_BR
dc.subjectArticulação temporomandibularpt_BR
dc.subject.otherlanguageTemporomandibular jointpt_BR
dc.description.abstractWe have previously demonstrated that peripheral administration of 15d-PGJ(2) in the Temporomandibular joint (TMJ) of rats can prevent nociceptor sensitization, mediated by peroxisome proliferator activated receptor-gamma (PPAR-gamma), and kappa- and delta- opioid receptors. However, the mechanism that underlies the signaling of PPAR-gamma (upon activation by 15d-PGJ(2)) to induce antinociception, and how the opioid receptors are activated via 15d-PGJ(2) are not fully understood. This study demonstrates that peripheral antinociceptive effect of 15d-PGJ(2) is mediated by PPAR-gamma expressed in the inflammatory cells of TMJ tissues. Once activated by 15d-PGJ(2), PPAR-gamma induces the release of beta-endorphin and dynorphin, which activates kappa- and delta-opioid receptors in primary sensory neurons to induce the antinociceptive effect. (C) 2016 Elsevier Ltd. All rights reserved.en
dc.description.abstractWe have previously demonstrated that peripheral administration of 15d-PGJ(2) in the Temporomandibular joint (TMJ) of rats can prevent nociceptor sensitization, mediated by peroxisome proliferator activated receptor-gamma (PPAR-gamma), and kappa- and delta- opioid receptors. However, the mechanism that underlies the signaling of PPAR-gamma (upon activation by 15d-PGJ(2)) to induce antinociception, and how the opioid receptors are activated via 15d-PGJ(2) are not fully understood. This study demonstrates that peripheral antinociceptive effect of 15d-PGJ(2) is mediated by PPAR-gamma expressed in the inflammatory cells of TMJ tissues. Once activated by 15d-PGJ(2), PPAR-gamma induces the release of beta-endorphin and dynorphin, which activates kappa- and delta-opioid receptors in primary sensory neurons to induce the antinociceptive effectpt
dc.relation.ispartofProstaglandins, leukotrienes, and essential fatty acidspt_BR
dc.relation.ispartofabbreviationProstaglandins leukot essent fatty acidspt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherChurchill Livingstone/Elsevierpt_BR
dc.date.issued2016pt_BR
dc.date.monthofcirculationJulypt_BR
dc.identifier.citationProstaglandins, Leukotrienes And Essential Fatty Acids (plefa). ELSEVIER SCI LTD, n. 110, p. 27 - 34.pt_BR
dc.language.isoengpt_BR
dc.description.volume110pt_BR
dc.description.firstpage27pt_BR
dc.description.lastpage34pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.sourceWOSpt_br
dc.identifier.issn0952-3278pt_BR
dc.identifier.eissn1532-2823pt_BR
dc.identifier.wosidWOS:000378184900004pt_BR
dc.identifier.doi10.1016/j.plefa.2016.05.009pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S095232781530065X?via%3Dihubpt_BR
dc.description.sponsorshipCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsorshipCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORpt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsorship1CAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumber483988/2012pt_BR
dc.description.sponsordocumentnumber1830/2010pt_BR
dc.description.sponsordocumentnumber2011/00683-5pt_BR
dc.date.available2016-12-06T18:30:47Z-
dc.date.accessioned2016-12-06T18:30:47Z-
dc.description.provenanceMade available in DSpace on 2016-12-06T18:30:47Z (GMT). No. of bitstreams: 1 000378184900004.pdf: 881332 bytes, checksum: e2ddac0927b252ff4e74edc049c63506 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320122-
dc.contributor.departmentInformação não localizadapt_BR
dc.contributor.departmentInformação não localizadapt_BR
dc.contributor.departmentInformação não localizadapt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.identifier.source000378184900004-
dc.creator.orcidInformação não localizadapt_BR
dc.creator.orcidInformação não localizadapt_BR
dc.creator.orcidInformação não localizadapt_BR
dc.creator.orcid0000-0003-1068-3039pt_BR
dc.type.formArtigo-
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