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Type: Artigo de periódico
Title: A multicenter feasibility study of chronic graft-versus-host disease according to the National Institute of Health criteria: efforts to establish a Brazil-Seattle consortium as a platform for future collaboration in clinical trials
Author: Vigorito, Afonso Celso
Bouzas, Luis Fernando da Silva
Moreira, Maria Cláudia Rodrigues
Funke, Vaneuza Araújo Moreira
Colturato, Virgílio Antonio Rensi
Pedro, Andréia
Souza, Clarissa Vasconcellos de
Nunes, Elenaide Coutinho
Miranda, Eliana Cristina Martins
Camacho, Kátia
Mauad, Marcos Augusto
Correa, Maria Elvira Pizzigatti
Silva, Márcia de Matos
Sousa, Mair Pedro de
Tavares, Rita de Cássia Barbosa da Silva
Lee, Stephanie Joi
Flowers, Mary Evelyn Dantas
Abstract: BACKGROUND: New criteria for the diagnosis and classification of chronic graft-versus-host disease were developed in 2005 for the purpose of clinical trials with a consensus sponsored by the National Institute of Health. OBJECTIVES: The aim of this study is to present the results of a multicenter pilot study performed by the Brazil-Seattle chronic graft-versus-host disease consortium to determine the feasibility of using these criteria in five Brazilian centers. METHODS: The study was performed after translation of the consensus criteria into Portuguese and training. A total of 34 patients with National Institute of Health chronic graft-versus-host disease were enrolled in the pilot study between June 2006 and May 2009. RESULTS: Of the 34 patients, 26 (76%) met the criteria of overlap syndrome and eight (24%) the classic subcategory. The overall severity of disease was moderate in 21 (62%) and severe in 13 (38%) patients. The median time from transplant to onset of chronic graft-versus-host disease was 5.9 months (Range: 3 - 16 months); the median time for the overlap syndrome subcategory was 5.9 months (Range: 3 - 10 months) and for the classic subcategory, it was 7.3 months (Range: 3 - 16 months). At a median follow up of 16.5 months (Range: 4 - 39 months), overall survival was 75%. CONCLUSIONS: It was feasible to use the National Institute of Health consensus criteria for the diagnosis and scoring of chronic graft-versus-host disease in a Brazilian prospective multicenter study. More importantly, a collaborative hematopoietic cell transplantation network was established in Brazil offering new opportunities for future clinical trials in chronic graft-versus-host disease and in other areas of research involving hematopoietic stem cell transplantation.
Subject: Hematopoietic stem cell transplantation
Chronic graft versus host disease
NIH consensus
Editor: Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea
Citation: Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, v. 33, n. 4, p. 283-289, 2011.
Rights: aberto
Identifier DOI: 10.5581/1516-8484.20110078
Date Issue: 1-Jan-2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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