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Type: Artigo de periódico
Title: New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis
Author: Silva, Geraldo H.
Teles, Helder L.
Trevisan, Henrique C.
Bolzani, Vanderlan da S.
Young, Maria C. M.
Pfenning, Ludwig H.
Eberlin, Marcos N.
Haddad, Renato
Costa-Neto, Claudio M.
Araújo, Ângela R.
Abstract: Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays.
Dois novos metabólitos, 2,4-diidroxi-5,6-dimetil benzoato de etila (1) e phomopsilactona (2) foram isolados de Phomopsis cassiae, um fungo endofítico de Cassia spectabilis. As estruturas destes compostos foram elucidadas por dados espectrométricos de 1D e 2D RMN, EM e IV. As substâncias 1 e 2 exibiram forte atividade antifúngica contra os fungos fitopatogênicos Cladosporium cladosporioides e C. sphaerospermum, bem como citotoxidade contra a linhagem celular de tumor cervical humano (HeLa), em experimentos in vitro.
Subject: endophytic fungi
Phomopsis cassiae
Cassia spectabilis
cytotoxic metabolites
antifungal activity
Editor: Sociedade Brasileira de Química
Citation: Journal of the Brazilian Chemical Society. Sociedade Brasileira de Química, v. 16, n. 6b, p. 1463-1466, 2005.
Rights: aberto
Identifier DOI: 10.1590/S0103-50532005000800029
Date Issue: 1-Nov-2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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