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|Title:||Detection of putative stem-cell markers in invasive ductal carcinoma of the breast by immunohistochemistry: does it improve prognostic/predictive assessments?|
|Author:||Oliveira, Rodrigo V.|
Souza, Valéria B.
Souza, Philipi C.
Soares, Fernando A.
Rocha, Rafael M.
Schenka, André A.
|Abstract:||Experimental evidences from the last 2 decades supports the existence of a special type of neoplastic cell with stem-like features [cancer stem cell (CSC)] and their role in the pathophysiology and therapeutic resistance of breast cancer However, their clinical value in human breast cancer has not been fully determined. Materials and Methods: An immunohistochemistry panel of 10 putative CSC markers (CD34, C-KIT, CD10, SOX-2, OCT 3/4, p63, CD24, CD44, CD133, and ESA/EPCAM) was applied to 74 cases of breast cancer, followed in a Regional Cancer Center of Minas Gerais State, Brazil, from 2004 to 2006. Possible associations between CSC markers and classic variables of clinicopathologic relevance were investigated. Results: The most frequently positive CSC markers were CD44, CD24, CD133, and ESA (the others were present in <15% of the cases). Two CSC profiles were defined: CD24/CD44+ (CSC-1) and CD133+/ESA+ (CSC-2). CSC-1 was significantly associated to patients older than 40 years, tumors of <2.0 cm in diameter, early clinical stages (P < 0.05), and increased death risk of 4 times (P = 0.03|
95% confidence interval, 1.09-14.41). CSC-2 was related to increased relapse risk of 3.75 times (P = 0.04
95% confidence interval, 1.02-13.69). Conclusion: The detection of the most frequently positive CSC markers by immunohistochemistry is of clinicopathologic and prognostic relevance
|Subject:||Neoplasias da mama, Células-tronco neoplásicas|
|Editor:||Lippincott Williams & Wilkins|
|Citation:||Detection Of Putative Stem-cell Markers In Invasive Ductal Carcinoma Of The Breast By Immunohistochemistry: Does It Improve Prognostic/predictive Assessments?. Nature Publishing Group, v. 28, p. 59A-59A FEB-2015.|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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