Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/244234
Type: Artigo de periódico
Title: Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation And Damage In Exhaustive Exercise
Author: Beck
Wladimir Rafael; Botezelli
Jose Diego; Pauli
Jose Rodrigo; Ropelle
Eduardo Rochete; Gobatto
Claudio Alexandre
Abstract: It is well documented that exhaustive physical exercise leads to inflammation and skeletal muscle tissue damage. With this in mind, melatonin has been acutely administered before physical exercise; nevertheless, the use of melatonin as an ergogenic agent to prevent tissue inflammation and damage remains uncertain. We evaluated the effects of melatonin on swimming performance, muscle inflammation and damage and several physiological parameters after exhaustive exercise at anaerobic threshold intensity (iLAn) performed during light or dark circadian periods. The iLAn was individually determined and two days later, the animals performed an exhaustive exercise bout at iLAn 30 minutes after melatonin administration. The exercise promoted muscle inflammation and damage, mainly during the dark period, and the exogenous melatonin promoted a high ergogenic effect. The expressive ergogenic effect of melatonin leads to longer periods of muscle contraction, which superimposes a possible melatonin protective effect on the tissue damage and inflammation.
Subject: Nf-kappa-b
Rat Skeletal-muscle
Nitric-oxide Synthase
Liver-glycogen Levels
Swimming Exercise
Inducible Isoform
Oxidative Stress
Performance
Expression
Responses
Country: LONDON
Editor: NATURE PUBLISHING GROUP
Citation: Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation And Damage In Exhaustive Exercise. Nature Publishing Group, v. 5, p. DEC-2015.
Rights: aberto
Identifier DOI: 10.1038/srep18065
Address: http://www.nature.com/articles/srep18065
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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