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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleNew Transcription Factors Involved With Postnatal Ventral Prostate Gland Development In Male Wistar Rats During The First Weekpt_BR
dc.contributor.authorNishanpt_BR
dc.contributor.authorUmar; Damas-Souzapt_BR
dc.contributor.authorDanilo M.; Barbosapt_BR
dc.contributor.authorGuilherme Oliveira; Muhammadpt_BR
dc.contributor.authorNawshad; Rahimpt_BR
dc.contributor.authorAbdur; Carvalhopt_BR
dc.contributor.authorHernandes F.pt_BR
unicamp.author.emailumarnishan@ciitlahore.edu.pkpt_BR
unicamp.authorCarvalho, Hernandes F.] Univ Estadual Campinas, Dept Struct & Funct Biol, Sao Paulo, Brazilpt_BR
unicamp.author.external[Nishan, Umarpt
unicamp.author.externalDamas-Souza, Danilo M.pt
unicamp.author.externalBarbosa, Guilherme Oliveirapt
unicamp.author.external[Nishan, Umarpt
unicamp.author.externalMuhammad, Nawshadpt
unicamp.author.externalRahim, Abdur] COMSATS Inst Informat Technol, Interdisciplinary Res Ctr Biomed Mat IRCBM, Lahore, Pakistanpt
dc.subjectMouse Prostatept_BR
dc.subjectExpressionpt_BR
dc.subjectGenept_BR
dc.subjectMorphogenesispt_BR
dc.subjectCancerpt_BR
dc.subjectRolespt_BR
dc.subjectDifferentiationpt_BR
dc.subjectPhosphatasept_BR
dc.subjectDynamicspt_BR
dc.subjectRevealspt_BR
dc.description.abstractAims: The high incidence in men of prostatic diseases, including benign and malignant tumors, makes the understanding of prostate development and biology very important. Understanding the organogenesis of the prostate gland has been a substantial challenge as "prostatic code" is not well defined at the present time. The novelty of this work lies in unveiling new transcription factors (TFs) during neonatal ventral prostate (VP) gland development in male Wistar rats. Main methods: The techniques of qRT-PCR and immunohistochemistry have been employed to perform this work while the VP gland was obtained from neonatal rats at day zero (the day of birth) day 3 and 6. Key findings: 16 TFs were studied and we found an increased expression of Eya2, Lhrh and Znf142, invariable levels of Znf703 and Dbp, and decreased expression of 11 others at postnatal development day 3 and 6 as compared to day zero. ZNF703 was found by immunohistochemistry in epithelial cells at days 0,3 and 6. qRT-PCR for Eya2 and Dmrt2 showed the highest and lowest fold change for them respectively, and immunohistochemistly showed that the former is being expressed at the three selected time points while the latter appears to be diminishing with very few cells expressing it until day 6. Significance: Results from this work is reporting the role of these TFs for the first time and will significantly contribute to the current understanding of the development and branching morphogenesis of the neonatal VP gland during the first week of postnatal development. (C) 2015 Elsevier Inc All rights reserved.en
dc.relation.ispartofLIFE SCIENCESpt_BR
dc.publisher.countryOXFORDpt_BR
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDpt_BR
dc.date.issued2015-DECpt_BR
dc.identifier.citationNew Transcription Factors Involved With Postnatal Ventral Prostate Gland Development In Male Wistar Rats During The First Week. Pergamon-elsevier Science Ltd, v. 143, p. 168-173 DEC-2015.pt_BR
dc.language.isoenpt_BR
dc.description.volume143pt_BR
dc.description.firstpage168pt_BR
dc.description.lastpage173pt_BR
dc.rightsembargopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0024-3205pt_BR
dc.identifier.wosidWOS:000366956600021pt_BR
dc.identifier.doi10.1016/j.lfs.2015.10.036pt_BR
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S002432051530062Xpt_BR
dc.description.sponsorshipWorld Academy of Sciences (TWAS)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2016-06-07T13:35:58Z-
dc.date.accessioned2016-06-07T13:35:58Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:35:58Z (GMT). No. of bitstreams: 1 wos_000366956600021.pdf: 1022940 bytes, checksum: cc796cd36cdc18c49bcd210ef0495d25 (MD5) Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/244230-
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