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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAsymptomatic Carotid Stenosis Is Associated With Gray And White Matter Damagept_BR
dc.contributor.authorAvelarpt_BR
dc.contributor.authorWagner M.; D'Abreupt_BR
dc.contributor.authorAnelyssa; Coanpt_BR
dc.contributor.authorAna C.; Limapt_BR
dc.contributor.authorFabricio Oliveira; Guimaraespt_BR
dc.contributor.authorRachel; Yassudapt_BR
dc.contributor.authorClarissa L.; Oliveirapt_BR
dc.contributor.authorGermano P.; Guillaumonpt_BR
dc.contributor.authorAna T.; Filhopt_BR
dc.contributor.authorAugusto A.; Minpt_BR
dc.contributor.authorLi L.; Cendespt_BR
dc.contributor.authorFernandopt_BR
unicamp.author.emailfcendes@unicamp.brpt_BR
unicamp.authorCendes, Fernando] Univ Estadual Campinas, Neuroimaging Lab, Dept Neurol, Campinas, SP, Brazilpt_BR
unicamp.authorGuillaumon, Ana T.] Univ Estadual Campinas, Dept Surg, Campinas, SP, Brazilpt_BR
unicamp.author[Filho, Augusto A.] Univ Estadual Campinas, Dept Radiol, Campinas, SP, Brazilpt_BR
unicamp.author.external[Avelar, Wagner M.pt
unicamp.author.externalD'Abreu, Anelyssapt
unicamp.author.externalCoan, Ana C.pt
unicamp.author.externalLima, Fabricio Oliveirapt
unicamp.author.externalGuimaraes, Rachelpt
unicamp.author.externalYassuda, Clarissa L.pt
unicamp.author.externalMin, Li L.pt
unicamp.author.external[Oliveira, Germano P.pt
dc.subjectCognitive Impairmentpt_BR
dc.subjectArtery Stenosispt_BR
dc.subjectOcclusive Diseasept_BR
dc.subjectHeart-failurept_BR
dc.subjectRiskpt_BR
dc.subjectMrpt_BR
dc.subjectAtherosclerosispt_BR
dc.subjectEndarterectomypt_BR
dc.subjectDementiapt_BR
dc.subjectSmartpt_BR
dc.description.abstractBackground Cognitive deficits in patients with asymptomatic carotid stenosis have been reported. The ultimate mechanism of cognitive deficits remains unclear and might be related to subtle structural brain damage. Aims The aim of the present study was to evaluate the presence of subtle white and grey matter abnormalities associated with asymptomatic carotid stenosis. Methods Twenty-five patients with asymptomatic >= 70%/occlusion carotid stenosis and 25 healthy controls, matched for gender and age, underwent 3 Tesla brain magnetic resonance imaging. Gray and white matter macrostructural abnormalities were evaluated with voxel-based morphometry using SPM8 software. White matter microstructural abnormalities were evaluated with diffusion tensor images with the Diffusion Toolbox package and tract-based spatial statistics from FMRIB Software Library. Results We observed significant macro-and microstructural white matter abnormalities, and these findings were diffuse and symmetrical in both hemispheres. In contrast, gray matter atrophy was observed in the areas corresponding to the anterior circulation of the hemisphere ipsilateral to the carotid stenosis. Conclusions Patients with asymptomatic carotid stenosis have different patterns of gray and white matter abnormalities. While the white matter damage is diffuse, the gray matter atrophy is localized in the territory of anterior circulation ipsilateral to the stenosis. The role of asymptomatic carotid stenosis in the gray matter damage must be further investigated with longitudinal studies and comparison with neuropsychological evaluation.en
dc.relation.ispartofINTERNATIONAL JOURNAL OF STROKEpt_BR
dc.publisher.countryHOBOKENpt_BR
dc.publisherWILEY-BLACKWELLpt_BR
dc.date.issued2015-DECpt_BR
dc.identifier.citationAsymptomatic Carotid Stenosis Is Associated With Gray And White Matter Damage. Wiley-blackwell, v. 10, p. 1197-1203 DEC-2015.pt_BR
dc.language.isoenpt_BR
dc.description.volume10pt_BR
dc.description.issuenumber8pt_BR
dc.description.firstpage1197pt_BR
dc.description.lastpage1203pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1747-4930pt_BR
dc.identifier.wosidWOS:000367673700010pt_BR
dc.identifier.doi10.1111/ijs.12574pt_BR
dc.identifier.urlhttp://wso.sagepub.com/content/10/8/1197.longpt_BR
dc.date.available2016-06-07T13:35:05Z-
dc.date.accessioned2016-06-07T13:35:05Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:35:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/244046-
Appears in Collections:Unicamp - Artigos e Outros Documentos

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