Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/243729
Type: Artigo de periódico
Title: Ghost Cells In Pilomatrixoma, Craniopharyngioma, And Calcifying Cystic Odontogenic Tumor: Histological, Immunohistochemical, And Ultrastructural Study
Author: Rumayor
Alicia; Carlos
Roman; Molina Kirsch
Hernan; Benevenuto de Andrade
Bruno A.; Romanach
Mario J.; de Almeida
Oslei Paes
Abstract: BackgroundPilomatrixoma, craniopharyngioma, and calcifying cystic odontogenic tumor are the main entities presenting ghost cells as an important histological feature, in spite their quite different clinical presentation; it seems that they share a common pathway in the formation of these cells. The aim of this study is to examine and compare the characteristics of ghost and other cells that form these lesions. MethodsForty-three cases including 21 pilomatrixomas, 14 craniopharyngiomas, and eight calcifying cystic odontogenic tumors were evaluated by immunohistochemistry for cytokeratins, CD138, -catenin, D2-40, Glut-1, FAS, CD10 and also by scanning electron microscopy. ResultsThe CKs, CD138, -catenin, Glut-1, FAS, and CD10 were more often expressed by transitional cells of craniopharyngioma and calcifying cystic odontogenic tumor, compared with pilomatrixoma. Basaloid cells of pilomatrixoma showed strong positivity for CD138 and CD10. Differences on expression pattern were identified in transitional and basal cells, as ghost cells were negative for most antibodies used, except by low expression for cytokeratins. By scanning electron microscopy, the morphology of ghost cells were similar in their fibrillar cytoplasm, but their pattern varied from sheets in pilomatrixoma to small clusters in craniopharyngioma and calcifying cystic odontogenic tumor. ConclusionsMechanisms involved in formation of ghost cells are unknown, but probably they follow different pathways as protein expression in the basal/transitional cells was not uniform in the three tumors studied.
Subject: Beta-catenin Gene
Expression
Keratinization
Epithelioma
Carcinoma
Mutations
Pathway
Skin
Country: HOBOKEN
Editor: WILEY-BLACKWELL
Citation: Ghost Cells In Pilomatrixoma, Craniopharyngioma, And Calcifying Cystic Odontogenic Tumor: Histological, Immunohistochemical, And Ultrastructural Study. Wiley-blackwell, v. 44, p. 284-290 APR-2015.
Rights: fechado
Identifier DOI: 10.1111/jop.12234
Address: http://onlinelibrary.wiley.com/doi/10.1111/jop.12234/abstract
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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