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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleFollowing The Spreading Of Brain Structural Changes In Alzheimer's Disease: A Longitudinal, Multimodal Mri Studypt_BR
dc.contributor.authorWeilerpt_BR
dc.contributor.authorMarina; Agostapt_BR
dc.contributor.authorFederica; Canupt_BR
dc.contributor.authorElisa; Copettipt_BR
dc.contributor.authorMassimiliano; Magnanipt_BR
dc.contributor.authorGiuseppe; Marconept_BR
dc.contributor.authorAlessandra; Paganipt_BR
dc.contributor.authorElisabetta; Figueredo Balthazarpt_BR
dc.contributor.authorMarcio Luiz; Comipt_BR
dc.contributor.authorGiancarlo; Falinipt_BR
dc.contributor.authorAndrea; Filippipt_BR
dc.contributor.authorMassimopt_BR
unicamp.author.emailfilippi.massimo@hsr.itpt_BR
unicamp.authorFigueredo Balthazar, Marcio Luiz] Univ Estadual Campinas, Lab Neuroimaging, Campinas, SP, Brazilpt_BR
unicamp.author.external[Weiler, Marinapt
unicamp.author.externalAgosta, Federicapt
unicamp.author.externalCanu, Elisapt
unicamp.author.externalPagani, Elisabettapt
unicamp.author.externalFilippi, Massimo] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Inst Expt Neurol, Div Neurosci,Neuroimaging Res Unit, I-20132 Milan, Italypt
unicamp.author.external[Magnani, Giuseppept
unicamp.author.externalComi, Giancarlopt
unicamp.author.externalFilippi, Massimo] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Inst Expt Neurol, Div Neurosci,Dept Neurol, I-20132 Milan, Italypt
unicamp.author.external[Marcone, Alessandra] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Div Neurosci, Dept Clin Neurosci, I-20132 Milan, Italypt
unicamp.author.external[Falini, Andrea] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Dept Neuroradiol, I-20132 Milan, Italypt
unicamp.author.external[Falini, Andrea] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, CERMAC, Div Neurosci, I-20132 Milan, Italypt
unicamp.author.external[Copetti, Massimiliano] IRCCS Osped Casa Sollievo Sofferenza, Biostat Unit, Foggia, Italypt
unicamp.author.external[Weiler, Marinapt
dc.subjectMild Cognitive Impairmentpt_BR
dc.subjectTensor-based Morphometrypt_BR
dc.subjectCerebral-blood-flowpt_BR
dc.subjectNormative Datapt_BR
dc.subjectFmript_BR
dc.subjectDementiapt_BR
dc.subjectSchizophreniapt_BR
dc.subjectConnectivitypt_BR
dc.subjectDiagnosispt_BR
dc.subjectBiomarkerpt_BR
dc.description.abstractBackground: Longitudinal MRI studies in Alzheimer's disease (AD) are one of the most reliable way to track brain changes along the course of the disease. Objective: To investigate the evolution of grey matter (GM) atrophy and white matter (WM) damage in AD patients, and to assess the relationships of MRI changes with baseline clinical and cognitive variables and their evolution over time. Methods: Clinical, neuropsychological, and MRI assessments (T1-weighted and diffusion tensor [DT]-MRI) were obtained from 14 patients with AD at baseline and after a 16 +/- 3 month period. Lumbar puncture was obtained at study entry. At baseline, AD patients were compared to 37 controls. GM atrophy progression was assessed with tensor-based morphometry and GM volumes of interest, and WM damage progression using tract-based spatial statistics and tractography. Results: At baseline, patients showed cortical atrophy in the medial temporal and parietal regions and a widespread pattern of WM damage involving the corpus callosum, cingulum, and temporo-occipital, parietal, and frontal WM tracts. During follow up, AD patients showed total GM atrophy, while total WM volume did not change. GM tissue loss was found in frontal, temporal, and parietal regions. In addition, AD patients showed a progression of WM microstructural damage to the corpus callosum, cingulum, fronto-parietal and temporo-occipital connections bilaterally. Patients with higher baseline cerebrospinal fluid total tau showed greater WM integrity loss at follow up. GM and WM changes over time did not correlate with each other nor with cognitive evolution. Conclusion: In AD, GM atrophy and WM tract damage are likely to progress, at least partially, independently. This study suggests that a multimodal imaging approach, which includes both T1-weighted and DT MR imaging, may provide additional markers to monitor disease progression.en
dc.relation.ispartofJOURNAL OF ALZHEIMERS DISEASEpt_BR
dc.publisher.countryAMSTERDAMpt_BR
dc.publisherIOS PRESSpt_BR
dc.date.issued2015pt_BR
dc.identifier.citationFollowing The Spreading Of Brain Structural Changes In Alzheimer's Disease: A Longitudinal, Multimodal Mri Study. Ios Press, v. 47, p. 995-1007 2015.pt_BR
dc.language.isoenpt_BR
dc.description.volume47pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage995pt_BR
dc.description.lastpage1007pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1387-2877pt_BR
dc.identifier.wosidWOS:000360931300018pt_BR
dc.identifier.doi10.3233/JAD-150196pt_BR
dc.identifier.urlhttp://content.iospress.com/articles/journal-of-alzheimers-disease/jad150196pt_BR
dc.date.available2016-06-07T13:33:15Z-
dc.date.accessioned2016-06-07T13:33:15Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:33:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/243656-
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