Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/243629
Type: Artigo de periódico
Title: Molecular Evolution Of Hoxa13 And The Multiple Origins Of Limbless Morphologies In Amphibians And Reptiles
Author: Singarete
Marina E.; Grizante
Mariana B.; Milograna
Sarah R.; Nery
Mariana F.; Kin
Koryu; Wagner
Guenter P.; Kohlsdorf
Tiana
Abstract: Developmental processes and their results, morphological characters, are inherited through transmission of genes regulating development. While there is ample evidence that cis-regulatory elements tend to be modular, with sequence segments dedicated to different roles, the situation for proteins is less clear, being particularly complex for transcription factors with multiple functions. Some motifs mediating protein-protein interactions may be exclusive to particular developmental roles, but it is also possible that motifs are mostly shared among different processes. Here we focus on HoxA13, a protein essential for limb development. We asked whether the HoxA13 amino acid sequence evolved similarly in three limbless clades: Gymnophiona, Amphisbaenia and Serpentes. We explored variation in omega (dN/dS) using a maximum-likelihood framework and HoxA13 sequences from 47 species. Comparisons of evolutionary models provided low omega global values and no evidence that HoxA13 experienced relaxed selection in limbless clades. Branch-site models failed to detect evidence for positive selection acting on any site along branches of Amphisbaena and Gymnophiona, while three sites were identified in Serpentes. Examination of alignments did not reveal consistent sequence differences between limbed and limbless species. We conclude that HoxA13 has no modules exclusive to limb development, which may be explained by its involvement in multiple developmental processes.
Subject: Foot-genital Syndrome
Body Plan
Evo-devo
Developmental Evolution
Phylogenetic Analysis
Positive Selection
Gene
Expression
Hoxa-13
Protein
Country: RIBEIRAO PRET
Editor: SOC BRASIL GENETICA
Citation: Molecular Evolution Of Hoxa13 And The Multiple Origins Of Limbless Morphologies In Amphibians And Reptiles. Soc Brasil Genetica, v. 38, p. 255-262 2015.
Rights: fechado
Identifier DOI: 10.1590/S1415-475738320150039
Address: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300255&lng=en&nrm=iso&tlng=en
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
wos_000361555100004.pdf615.46 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.