Combined Training Reduces Subclinical Inflammation In Obese Middle-age Men

Abstract

Purpose: We investigated the effects of 24 wk of combined training on proinflammatory and anti-inflammatory markers associated with obesity in obese middle-age men. Methods: Thirty obese men (48.73 1.04 yr; body mass index, 31.00 0.29 kgm(-2)) underwent 24 wk of combined training [CT (N = 17), aerobic (50%-85% of (V) over dot(2peak)) and resistance (6-10 maximum repetition [RM]) training)] three times per week, 60 min per session, or a control group (N = 13). Anthropometric measures, maximal strength for leg press and bench press, peak oxygen uptake ((V) over dotO(2peak)) and serum concentrations of C-reactive protein (CRP), tumor necrosis factor (TNF-), interleukin-6 (IL-6), IL-10, IL-15, resistin, leptin, and adiponectin were determined before (M1) and after 8 (M2), 16 (M3), and 24 (M4) wk of the experimental design. Results: Significant increases were observed in the maximal strength for bench press and leg press, (V) over dotO(2peak), and serum concentrations of adiponectin and IL-15 for CT. Concomitantly, significant decreases were observed in percentage body fat and serum concentrations of CRP, resistin, and leptin for CT after the experimental period. Conclusion: Twenty-four weeks of moderate- to high-intensity CT reduced markers of subclinical inflammation associated with obesity and improved insulin resistance and functional capabilities of obese middle-age men, regardless of dietary intervention and weight loss.