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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleA Dopant For Improved Sensitivity In Easy Ambient Sonic-spray Ionization Mass Spectrometry.pt_BR
dc.contributor.authorSantos, Jandyson Mpt_BR
dc.contributor.authorVendramini, Pedro Hpt_BR
dc.contributor.authorSchwab, Nicolas Vpt_BR
dc.contributor.authorEberlin, Marcos Npt_BR
dc.contributor.authorde Morais, Damila Rpt_BR
unicamp.authorJandyson M Santos, ThoMSon Mass Spectrometry Laboratory, University of Campinas-UNICAMP, Institute of Chemistry, Campinas, São Paulo, 13083-970, Brazil.pt_BR
unicamp.authorPedro H Vendramini, ThoMSon Mass Spectrometry Laboratory, University of Campinas-UNICAMP, Institute of Chemistry, Campinas, São Paulo, 13083-970, Brazil.pt_BR
unicamp.authorNicolas V Schwab, ThoMSon Mass Spectrometry Laboratory, University of Campinas-UNICAMP, Institute of Chemistry, Campinas, São Paulo, 13083-970, Brazil.pt_BR
unicamp.authorMarcos N Eberlin, ThoMSon Mass Spectrometry Laboratory, University of Campinas-UNICAMP, Institute of Chemistry, Campinas, São Paulo, 13083-970, Brazil.pt_BR
unicamp.authorDamila R de Morais, ThoMSon Mass Spectrometry Laboratory, University of Campinas-UNICAMP, Institute of Chemistry, Campinas, São Paulo, 13083-970, Brazil.pt_BR
dc.subject3-nitrobenzonitrile And Mass Spectrometrypt_BR
dc.subjectDesi-mspt_BR
dc.subjectEasi-mspt_BR
dc.subjectDopantpt_BR
dc.description.abstractRecently, 3-nitrobenzonitrile (3-NBN) has been used to improve sensitivity of sonic-spray ionization mass spectrometry. Easy ambient sonic-spray ionization (EASI) is one of the simplest, gentlest and most used spray-based desorption/ionization ambient techniques, but limited sensitivity has been commonly taken as its major drawback. Herein we investigate the use of 3-NBN as a dopant in EASI-MS for improved sensitivity. Using a few typical EASI samples as test cases, the presence of 10 ppm (µg ml(-1) ) of 3-NBN in the spray solvent showed two to fourfold gains in EASI-MS sensitivity as measured both by total ion current and S/N ratios, accompanied with significant reductions in chemical noise. Sensitivity for DESI using 3-NBN as a dopant also improved and dopant DESI versus dopant EASI sensitivities were compared. The use of solvent dopants seems therefore to be a promising strategy to improve sensitivity for spray-based ambient MS techniques. Copyright © 2015 John Wiley & Sons, Ltd.en
dc.relation.ispartofJournal Of Mass Spectrometry : Jmspt_BR
dc.relation.ispartofabbreviationJ Mass Spectrompt_BR
dc.date.issued2016-Janpt_BR
dc.identifier.citationJournal Of Mass Spectrometry : Jms. v. 51, n. 1, p. 53-61, 2016-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume51pt_BR
dc.description.firstpage53-61pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1096-9888pt_BR
dc.identifier.doi10.1002/jms.3726pt_BR
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jms.3726/abstractpt_BR
dc.date.available2016-05-23T19:44:02Z-
dc.date.accessioned2016-05-23T19:44:02Z-
dc.description.provenanceMade available in DSpace on 2016-05-23T19:44:02Z (GMT). No. of bitstreams: 1 pmed_26757072.pdf: 1041112 bytes, checksum: 1b1b92ee01fe7a4d5f8289402b288995 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/236120-
dc.identifier.idPubmed26757072pt_BR
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