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Type: Artigo de periódico
Title: A Dopant For Improved Sensitivity In Easy Ambient Sonic-spray Ionization Mass Spectrometry.
Author: Santos, Jandyson M
Vendramini, Pedro H
Schwab, Nicolas V
Eberlin, Marcos N
de Morais, Damila R
Abstract: Recently, 3-nitrobenzonitrile (3-NBN) has been used to improve sensitivity of sonic-spray ionization mass spectrometry. Easy ambient sonic-spray ionization (EASI) is one of the simplest, gentlest and most used spray-based desorption/ionization ambient techniques, but limited sensitivity has been commonly taken as its major drawback. Herein we investigate the use of 3-NBN as a dopant in EASI-MS for improved sensitivity. Using a few typical EASI samples as test cases, the presence of 10 ppm (µg ml(-1) ) of 3-NBN in the spray solvent showed two to fourfold gains in EASI-MS sensitivity as measured both by total ion current and S/N ratios, accompanied with significant reductions in chemical noise. Sensitivity for DESI using 3-NBN as a dopant also improved and dopant DESI versus dopant EASI sensitivities were compared. The use of solvent dopants seems therefore to be a promising strategy to improve sensitivity for spray-based ambient MS techniques. Copyright © 2015 John Wiley & Sons, Ltd.
Subject: 3-nitrobenzonitrile And Mass Spectrometry
Citation: Journal Of Mass Spectrometry : Jms. v. 51, n. 1, p. 53-61, 2016-Jan.
Rights: fechado
Identifier DOI: 10.1002/jms.3726
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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