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Type: Artigo de periódico
Title: Survival And Graft-versus-host Disease In Patients Receiving Peripheral Stem Cell Compared To Bone Marrow Transplantation From Hla-matched Related Donor: Retrospective Analysis Of 334 Consecutive Patients.
Author: Campregher, Paulo Vidal
Hamerschlak, Nelson
Colturato, Vergilio Antonio Renzi
Mauad, Marcos Augusto
de Souza, Mair Pedro
Bouzas, Luis Fernando da Silva
Tavares, Rita de Cássia B
Barros, José Carlos
Chiattone, Ricardo
Paz, Alessandra
Silla, Lucia
Vigorito, Afonso Celso
Miranda, Eliane
Funke, Vaneuza Araújo Moreira
Flowers, Mary Evelyn
Abstract: The objective of this study was to compare the major transplant outcomes between patients receiving hematopoietic stem cell transplantation (HSCT) from bone marrow (BM) or peripheral blood stem cells (PBSC). All consecutive HSCT patients using BM or PBSC from an HLA-matched related donors for haematological malignancies after high intensity conditioning at seven Brazilian transplant centres between January 2008 and December 2009 were retrospectively evaluated. In the study period, 334 patients were treated in the centres and included in the evaluation. The cumulative incidence of grades II-IV and III-IV acute graft-versus-host disease (GVHD) at one year was 36.7% and 9.7% for BM recipients and 34.4% and 15.1% for PBSC recipients, respectively (not statistically different). The cumulative incidence of chronic GVHD at three years was 53.7% and 79.8% (HR 1.93; 95% CI 1.38-2.69, P < 0.001) for BM and PBSC, respectively. Median overall survival was 2.85 and 2.39 years for BM and PBSC recipients, respectively (HR 1.19; 95% CI, 0.84-1.68, P = 0.34). Our results confirm previous findings of increased chronic GVHD incidence in patients receiving PBSC when compared to patients receiving BM as the graft source in HSCT. Acute GVHD incidence, progression-free survival and overall survival were not different between the groups.
Subject: Haematological Neoplasms
Hematopoietic Stem Cell Transplantation
Multicenter Study
Peripheral Blood Stem Cell Transplantation
Citation: European Journal Of Haematology. v. 95, n. 5, p. 421-425, 2015-Nov.
Rights: embargo
Identifier DOI: 10.1111/ejh.12508
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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