Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/235790
Type: Artigo de periódico
Title: Unraveling Brazilian Indian Population Prostate Good Health: Clinical, Anthropometric And Genetic Features.
Author: Lima Junior, Mario M de
Reis, Leonardo O
Ferreira, Ubirajara
Cardoso, Ulieme Oliveira
Barbieri, Raquel Bueno
Mendonça, Gustavo B de
Ward, Laura S
Abstract: To compare dietary, lifestyle, clinical, anthropometric, genetic and prostatic features of Brazilian Indians and non-Indians (Amazon). 315 men, 228 Indians and 89 non-Indians, ≥ 40 years old were submitted to digital rectal examination, serum prostate specific antigen (PSA), testosterone, TP53 and GSTP1 genotyping, anthropometric, lifestyle, dietary, personal and familial medical history. Prostatic symptoms were evaluated with the International Prostate Symptom Score (IPSS). Macuxis and Yanomamis represented 43.6% and 14.5% of Indians respectively who spontaneously referred no prostate symptoms. Mean IPSS was 7, range 3-19, with only 15% of moderate symptoms (score 8-19); Mean age was 54.7 years, waist circumference 86.6 cm, BMI 23.9 kg/m(2). Yanomamis presented both lower BMI (21.4 versus 24.8 and 23.3, p=0,001) and prostate volume than Macuxis and other ethnic groups (15 versus 20, p=0.001). Testosterone (414 versus 502 and 512, p=0.207) and PSA (0.48 versus 0.6 and 0.41, p=0.349) were similar with progressive PSA increase with aging. Val/Val correlated with lower PSA (p=0.0361). Indians compared to control population presented: - TP53 super representation of Arg/Arg haplotype, 74.5% versus 42.5%, p<0.0001. -GSTP1 Ile/Ile 35.3% versus 60.9%; Ile/Val 45.9% versus 28.7%; Val/Val 18.8% versus 10.3%; p=0.0003. Observed specific dietary, lifestyle, anthropometric and genetic profile for TP53 and GSTP1 may contribute to Brazilian Indian population prostate good health.
Subject: Adult
Age Factors
Aged
Aged, 80 And Over
Anthropometry
Brazil
Digital Rectal Examination
Food Habits
Glutathione S-transferase Pi
Humans
Indians, South American
Life Style
Male
Middle Aged
Organ Size
Polymorphism, Genetic
Prostate
Prostate-specific Antigen
Prostatic Diseases
Risk Factors
Statistics, Nonparametric
Tumor Suppressor Protein P53
Citation: International Braz J Urol : Official Journal Of The Brazilian Society Of Urology. v. 41, n. 2, p. 344-352
Rights: embargo
Address: http://www.ncbi.nlm.nih.gov/pubmed/26005978
Appears in Collections:Unicamp - Artigos e Outros Documentos

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