Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/235746
Type: Artigo de periódico
Title: Serum Interleukin-17 Levels Are Associated With Nephritis In Childhood-onset Systemic Lupus Erythematosus.
Author: Peliçari, Karina de Oliveira
Postal, Mariana
Sinicato, Nailú Angelica
Peres, Fernando Augusto
Fernandes, Paula Teixeira
Marini, Roberto
Costallat, Lilian Tereza Lavras
Appenzeller, Simone
Abstract: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age- and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits. The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p=0.009). We observed an association between serum IL-17 levels and active nephritis (p=0.01) and migraines (p=0.03). Serum IL-17 levels were not associated with disease activity (p=0.32), cumulative damage (p=0.34), or medication use (p=0.63). IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus.
Subject: Adolescent
Adult
Age Of Onset
Anxiety
Brazil
Case-control Studies
Child
Cross-sectional Studies
Enzyme-linked Immunosorbent Assay
Family
Female
Humans
Interleukin-17
Lupus Erythematosus, Systemic
Male
Nephritis
Severity Of Illness Index
Young Adult
Citation: Clinics (são Paulo, Brazil). v. 70, n. 5, p. 313-317, 2015-May.
Rights: fechado
Identifier DOI: 10.6061/clinics/2015(05)01
Address: http://www.ncbi.nlm.nih.gov/pubmed/26039945
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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