Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/235741
Type: Artigo de periódico
Title: Mobilization And Collection Of Cd34(+) Cells For Autologous Transplantation Of Peripheral Blood Hematopoietic Progenitor Cells In Children: Analysis Of Two Different Granulocyte-colony Stimulating Factor Doses.
Author: Eid, Kátia Aparecida de Brito
Miranda, Eliana Cristina Martins
Aguiar, Simone Dos Santos
Abstract: The use of peripheral hematopoietic progenitor cells (HPCs) is the cell choice in autologous transplantation. The classic dose of granulocyte-colony stimulating factor (G-CSF) for mobilization is a single daily dose of 10μg/kg of patient body weight. There is a theory that higher doses of granulocyte-colony stimulating factor applied twice daily could increase the number of CD34(+) cells collected in fewer leukapheresis procedures. The aim of this study was to compare a fractionated dose of 15μg G-CSF/kg of body weight and the conventional dose of granulocyte-colony stimulating factor in respect to the number of leukapheresis procedures required to achieve a minimum collection of 3×10(6) CD34(+) cells/kg body weight. Patients were divided into two groups: Group 10 - patients who received a single daily dose of 10μg G-CSF/kg body weight and Group 15 - patients who received a fractioned dose of 15μg G-CSF/kg body weight daily. The leukapheresis procedure was carried out in an automated cell separator. The autologous transplantation was carried out when a minimum number of 3×10(6) CD34(+) cells/kg body weight was achieved. Group 10 comprised 39 patients and Group 15 comprised 26 patients. A total of 146 apheresis procedures were performed: 110 (75.3%) for Group 10 and 36 (24.7%) for Group 15. For Group 10, a median of three (range: 1-7) leukapheresis procedures and a mean of 8.89×10(6) CD34(+) cells/kg body weight (±9.59) were collected whereas for Group 15 the corresponding values were one (range: 1-3) and 5.29×10(6) cells/kg body weight (±4.95). A statistically significant difference was found in relation to the number of apheresis procedures (p-value <0.0001). To collect a minimum target of 3×10(6) CD34(+) cells/kg body weight, the administration of a fractionated dose of 15μg G-CSF/kg body weight significantly decreased the number of leukapheresis procedures performed.
Subject: Autologous Transplantation
Granulocyte Colony-stimulating Factor
Hematopoietic Stem Cell Mobilization
Leukapheresis
Citation: Revista Brasileira De Hematologia E Hemoterapia. v. 37, n. 3, p. 160-166
Rights: fechado
Identifier DOI: 10.1016/j.bjhh.2015.02.006
Address: http://www.ncbi.nlm.nih.gov/pubmed/26041417
Appears in Collections:Unicamp - Artigos e Outros Documentos

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