Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/235679
Type: Artigo de periódico
Title: The Role Of Kir2dl3/hla-c*0802 In Brazilian Patients With Rheumatoid Vasculitis.
Author: Nishimura, Wester Eidi
Sachetto, Zoraida
Costallat, Lilian Teresa Lavras
Yazbek, Michel Alexandre
Londe, Ana Carolina Santos
Guariento, Edilaine Gildo
Marques, Silvia Barbosa Dutra
Bertolo, Manoel Barros
Abstract: Rheumatoid arthritis is a polygenically controlled systemic autoimmune disease. Rheumatoid vasculitis is an important extra-articular phenotype of rheumatoid arthritis that can result in deep cutaneous ulcers. The objective of this study was to establish a correlation between the frequency of major histocompatibility complex class I/II alleles and killer immunoglobulin-like receptor genotypes in patients with cutaneous rheumatoid vasculitis. Using the Scott & Bacon 1984 criteria to diagnose rheumatoid vasculitis and after excluding any other causes such as diabetes, atherosclerosis, adverse drug reactions, infection, and smoking, patients who met the criteria were selected. All of the selected rheumatoid vasculitis patients presented deep cutaneous ulcers. Identification of the major histocompatibility complex class I/II and killer immunoglobulin-like receptor genotypes was performed by polymerase chain reaction assays of samples collected from the 23 rheumatoid vasculitis patients as well as from 80 controls (40 non-rheumatoid vasculitis RA control patients and 40 healthy volunteers). An association between the presence of the HLA-DRB1*1402 and HLA-DRB1*0101 alleles and cutaneous lesions in rheumatoid vasculitis patients and a correlation between the inhibitor KIR2DL3 and the HLA-C*0802 ligand in rheumatoid vasculitis patients were found. An association was found between the presence of the HLA-DRB1*1402 and HLA-DRB1*0101 alleles and the development of cutaneous lesions in rheumatoid vasculitis patients. Additionally, the HLA-C*0802 ligand protects these individuals from developing cutaneous lesions.
Subject: Adolescent
Adult
Aged
Alleles
Arthritis, Rheumatoid
Brazil
Female
Flow Cytometry
Genotype
Hla-c Antigens
Hla-drb1 Chains
Humans
Major Histocompatibility Complex
Male
Middle Aged
Polymerase Chain Reaction
Receptors, Kir
Receptors, Kir2dl3
Rheumatoid Vasculitis
Skin Diseases, Vascular
Young Adult
Citation: Clinics (são Paulo, Brazil). v. 70, n. 6, p. 408-412, 2015-Jun.
Rights: fechado
Identifier DOI: 10.6061/clinics/2015(06)04
Address: http://www.ncbi.nlm.nih.gov/pubmed/26106958
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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