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Type: Artigo de periódico
Title: Antimoniais empregados no tratamento da leishmaniose: estado da arte
Title Alternative: Antimonials employed in the treatment of leishmaniaisis: the state of the art
Author: Rath, Susanne
Trivelin, Luciano Augusto
Imbrunito, Talitha Rebecca
Tomazela, Daniela Maria
Jesús, Marcelo Nunes de
Marzal, Percy Calvo
Andrade Junior, Heitor Franco de
Tempone, André Gustavo
Abstract: Antimony preparations are the drugs of choice for the treatment of leishmaniasis over 90 years, a disease that currently affects 12 million people worldwide. Its introduction was based on 19th century concepts of therapeutic effects of metal salts as arsenicals and other metals, most of them abandoned due to toxic effects or better drugs. In the last three decades, there was a great improvement in the knowledge of cell biology and immunology of those infections, but chemotherapy has not been improved in the same strength. The structure and mechanism of action of the two pentavalent antimonial drugs of choice, meglumine antimoniate and sodium stibogluconate, are not well known and the contamination of those pharmaceutical by toxic contaminants have been verified.
Subject: antimony
Editor: Sociedade Brasileira de Química
Citation: Química Nova. Sociedade Brasileira de Química, v. 26, n. 4, p. 550-555, 2003.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422003000400018
Date Issue: 1-Aug-2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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