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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleTaurine Supplementation Regulates Iκ-bα Protein Expression In Adipose Tissue And Serum Il-4 And Tnf-α Concentrations In Msg Obesity.pt_BR
dc.contributor.authorCaetano, Luiz Carlospt_BR
dc.contributor.authorBonfleur, Maria Lúciapt_BR
dc.contributor.authorRibeiro, Rosane Aparecidapt_BR
dc.contributor.authorNardelli, Tarlliza Romannapt_BR
dc.contributor.authorLubaczeuski, Camilapt_BR
dc.contributor.authordo Nascimento da Silva, Julianapt_BR
dc.contributor.authorCarneiro, Everardo Magalhãespt_BR
dc.contributor.authorBalbo, Sandra Lucineipt_BR
unicamp.authorTarlliza Romanna Nardelli, Laboratório de Pâncreas Endócrino e Metabolismo, Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.pt_BR
unicamp.authorEverardo Magalhães Carneiro, Laboratório de Pâncreas Endócrino e Metabolismo, Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.pt_BR
unicamp.author.externalLuiz Carlos Caetano, Laboratório de Fisiologia Endócrina e Metabolismo (LAFEM), Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE), Cascavel, PR, 858119-110, Brazil.pt
unicamp.author.externalMaria Lúcia Bonfleur, Laboratório de Fisiologia Endócrina e Metabolismo (LAFEM), Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE), Cascavel, PR, 858119-110, Brazil. mlbonfleur@hotmail.com.pt
unicamp.author.externalRosane Aparecida Ribeiro, Universidade Federal do Rio de Janeiro (UFRJ), Campus UFRJ-Macaé, Macaé, RJ, Brazil.pt
unicamp.author.externalCamila Lubaczeuski, Laboratório de Fisiologia Endócrina e Metabolismo (LAFEM), Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE), Cascavel, PR, 858119-110, Brazil.pt
unicamp.author.externalJuliana do Nascimento da Silva, Universidade Federal do Rio de Janeiro (UFRJ), Campus UFRJ-Macaé, Macaé, RJ, Brazil.pt
unicamp.author.externalSandra Lucinei Balbo, Laboratório de Fisiologia Endócrina e Metabolismo (LAFEM), Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE), Cascavel, PR, 858119-110, Brazil.pt
dc.subjectCytokinespt_BR
dc.subjectMonosodium Glutamatept_BR
dc.subjectObesitypt_BR
dc.subjectTaurine Supplementationpt_BR
dc.description.abstractObesity is usually associated with low-grade inflammation, which impairs insulin action. The amino acid, taurine (TAU), regulates glucose homeostasis and lipid metabolism and presents anti-inflammatory actions. Here, we evaluated whether inflammatory markers are altered in the serum and retroperitoneal adipose tissue of monosodium glutamate (MSG) obese rats, supplemented or not with TAU. Male Wistar rats received subcutaneous injections of MSG (4 mg/kg body weight/day, MSG group) or hypertonic saline (CTL) during the first 5 days of life. From 21 to 120 days of age, half of each of the MSG and CTL groups received 2.5 % TAU in their drinking water (CTAU and MTAU). At 120 days of age, MSG rats were obese and hyperinsulinemic. TAU supplementation reduced fat deposition without affecting insulinemia in MTAU rats. MSG rats presented increased pIκ-Bα/Iκ-Bα protein expression in the retroperitoneal adipose tissue. TAU supplementation decreased the ratio of pIκ-Bα/Iκ-Bα protein, possibly contributing to the increased Iκ-Bα content in MTAU adipose tissue. Furthermore, MSG obesity or supplementation did not alter TNF-α, IL-1β or IL-6 content in adipose tissue. In contrast, MSG rats presented lower serum TNF-α, IL-4 and IL-10 concentrations, and these alterations were prevented by TAU treatment. MSG obesity in rats was not associated with alterations in pro-inflammatory markers in retroperitoneal fat stores; however, reductions in the serum concentrations of anti-inflammatory cytokines and of TNF-α were observed. TAU treatment decreased adiposity, and this effect was associated with the normalization of circulating TNF-α and IL-4 concentrations in MTAU rats.en
dc.relation.ispartofEuropean Journal Of Nutritionpt_BR
dc.relation.ispartofabbreviationEur J Nutrpt_BR
dc.date.issued2015-Novpt_BR
dc.identifier.citationEuropean Journal Of Nutrition. , 2015-Nov.pt_BR
dc.language.isoengpt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1436-6215pt_BR
dc.identifier.doi10.1007/s00394-015-1114-8pt_BR
dc.identifier.urlhttp://download.springer.com/static/pdf/7/art%253A10.1007%252Fs00394-015-1114-8.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00394-015-1114-8&token2=exp=1462290657~acl=%2Fstatic%2Fpdf%2F7%2Fart%25253A10.1007%25252Fs00394-015-1114-8.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs00394-015-1114-8*~hmac=a1c10534138f101f488f23af36788e5c43c44a2eb8931ad856b3e9bd9a24c320pt_BR
dc.date.available2016-05-23T19:40:05Z-
dc.date.accessioned2016-05-23T19:40:05Z-
dc.description.provenanceMade available in DSpace on 2016-05-23T19:40:05Z (GMT). No. of bitstreams: 1 pmed_26621632.pdf: 1237815 bytes, checksum: 1a8011b027f6554222e478ff6111703b (MD5) Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235196-
dc.identifier.idPubmed26621632pt_BR
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