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Type: Artigo de periódico
Title: Antigenotoxic Effects of Piquia (Caryocar villosum) in Multiple Rat Organs
Author: Almeida, Mara Ribeiro
Castania Darin, Joana D'Arc
Hernandes, Livia Cristina
Aissa, Alexandre Ferro
Chiste, Renan Campos
Mercadante, Adriana Zerlotti
Greggi Antunes, Lusania Maria
Pires Bianchi, Maria Lourdes
Abstract: This study investigated the in vivo genotoxicity of piquia pulp (Caryocar villosum) and its potential antigenotoxicity on doxorubicin (DXR)-induced DNA damage by comet assay and micronucleus test. In addition, the phytochemicals present in piquia pulp were determined. Piquia fruit pulp (75, 150 or 300 mg/kg b.w.) was administered by gavage to Wistar rats for 14 days, and the animals received an injection of saline or DXR (15 mg/kg b.w., i.p.) 24 h before they were euthanized. The phytochemical analysis revealed the presence of carotenoids; phenolic compounds, including flavonoids; tannins and alpha-tocopherol in piquia pulp. No statistically significant differences were observed in the evaluated parameters, demonstrating the absence of cytotoxic and genotoxic effects of piquia pulp at all tested doses. In liver, kidney, cardiac and bone marrow cells, piquia significantly reduced the DNA damage induced by DXR. Our results showed that the lowest piquia dose caused the largest decrease in DNA damage and the highest dose caused the smallest decrease, demonstrating an inverse dose-response of piquia pulp. Furthermore, we observed a difference in the potential antigenotoxic effects in several tissues. In conclusion, our results demonstrated that piquia pulp was not genotoxic and inhibited the genotoxicity induced by DXR, but some of the protective effects that were observed depended on the doses and experimental conditions. Therefore, further investigations are needed to clarify how piquia pulp positively affects human health.
Subject: Polyphenols
Editor: Springer
Citation: Plant Foods For Human Nutrition. Springer, v.67, n.2, p.171-177, 2012
Rights: fechado
Identifier DOI: 10.1007/s11130-012-0291-3
Date Issue: 2012
Appears in Collections:FEA - Artigos e Outros Documentos

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