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Type: Artigo de periódico
Title: The Role of Dyslipidemia on Ocular Surface, Lacrimal and Meibomian Gland Structure and Function
Author: Modulo, Carolina Maria
Machado Filho, Elisio Bueno
Malki, Leonardo Tannus
Dias, Ana Carolina
de Souza, Jane Cristina
Oliveira, Helena C. F.
Jorge, Italo Cade
Santos Gomes, Isabele Beserra
Meyrelles, Silvana S.
Rocha, Eduardo Melani
Abstract: Purpose: Dyslipidemia is characterized by high lipid blood levels that are risk factors for cardiovascular diseases, which are leading causes of death. However, it is unclear whether dyslipidemia is a cause of the dry eye syndrome (DES). Therefore we determined in transgenic mice models of dyslipidemia, whether there is an association with DES development. Methods: Dyslipidemic models included male and female adult mice overexpressing apolipoprotein CIII (Apo CIII), LDL receptor knockout (LDLR-KO) and ApoE knockout (ApoE-KO). They were compared with age-and gender-matched C57BL/6 mice. Ocular health was evaluated based on corneal slit lamp assessment, phenol red thread test (PRT) and impression cytology. Blood lipid profiles and histology of meibomian and lacrimal glands were also evaluated. Effects of high-fat diet and aging were observed in LDLR-KO and ApoCIII strains, respectively. Results: Body weight and lacrimal gland weight were significantly higher in male mice compared to females of the same strain (P < 0.05). Body weight was significantly lower in LDLRKO mice receiving high lipid diet compared to their controls (P = 0.0043). ApoE-KO were hypercholesterolemic and ApoCIII hypertriglyceridemic while LDLR-KO showed increases in both parameters. The PRT test was lower in male LDLR-KO mice with high-fat diet than control mice with standard diet (P = 0.0273). Aging did not affect lacrimal structural or functional parameters of ApoCIII strain. Conclusions: DES development is not solely dependent on dyslipidemia in relevant mice models promoting this condition. On the other hand, lacrimal gland structure and function are differentially impacted by lipid profile changes in male and female mice. This dissociation suggests that other factors beside dyslipidemia impact on tear film dysfunction and DES development.
Subject: Apolipoprotein
Low density lipoprotein
Lacrimal gland
Meibomian gland
Dry eye
Ocular surface
Editor: Informa Healthcare
Citation: Current Eye Research. Informa Healthcare, v.37, n.4, p.300-308, 2012
Rights: fechado
Identifier DOI: 10.3109/02713683.2011.631720
Date Issue: 2012
Appears in Collections:IB - Artigos e Outros Documentos

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