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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleN-acetyltransferase-2 gene polymorphisms and prostate cancer susceptibility in Latin American patientspt_BR
dc.contributor.authorde Lima Junior, Mario Macielpt_BR
dc.contributor.authorReis, Leonardo Oliveirapt_BR
dc.contributor.authorTrindade Guilhen, Ana Carolinapt_BR
dc.contributor.authorGranja, Fabianapt_BR
dc.contributor.authorde Lima Oliveira, Mariana Nicolaupt_BR
dc.contributor.authorFerreira, Ubirajarapt_BR
dc.contributor.authorCunha, Lucas Leitept_BR
dc.contributor.authorWard, Laura Sterianpt_BR
unicamp.authorde Lima Junior, Mario Macielpt_BR
unicamp.authorReis, Leonardo Oliveirapt_BR
unicamp.authorTrindade Guilhen, Ana Carolinapt_BR
unicamp.authorGranja, Fabianapt_BR
unicamp.authorde Lima Oliveira, Mariana Nicolaupt_BR
unicamp.authorFerreira, Ubirajarapt_BR
unicamp.authorCunha, Lucas Leitept_BR
unicamp.author.externalWard, Laura Sterianpt
dc.subjectProstate cancerpt_BR
dc.subjectBenign prostatic hyperplasiapt_BR
dc.subjectRiskpt_BR
dc.subjectNAT2 genotypept_BR
dc.subjectAcetylationpt_BR
dc.subject.wosHETEROCYCLIC AMINESpt_BR
dc.subject.wosCOOKED FOODSpt_BR
dc.subject.wosRISKpt_BR
dc.subject.wosNAT2pt_BR
dc.subject.wosACETYLTRANSFERASESpt_BR
dc.subject.wosCARCINOGENESISpt_BR
dc.subject.wosGENOTYPEpt_BR
dc.subject.wosSMOKINGpt_BR
dc.subject.wosCOHORTpt_BR
dc.subject.wosCELLSpt_BR
dc.description.abstractWe investigated the role of N-acetyltransferases (NAT) in prostate cancer (PCa) susceptibility. NAT are polymorphic in the population and metabolize important carcinogenic products directly involved in the tumor initiation process. This prospective case-control study utilized the polymerase chain reaction-based restriction fragment length polymorphism method and comprised a cohort of consecutive 478 individuals: 126 men with prostate cancer; 101 men with benign prostatic hyperplasia (BPH); and a control health population of 177 female and 74 male blood donors from the same region. NAT2 slow or fast acetylators genotypes were determined by the combination of four variant alleles. Lifetime occupational history, dietary patterns, cigarette smoking and other anamnestic data were obtained by interviews. We were not able to find any correlation among smoking, dietary patterns, parameters of tumor aggressiveness or patient outcome and any NAT2 genotypes or phenotypes considered in separate or in different combinations. However, there was an association between NAT2T481C (OR = 0.47; 95% CI = 0.26-0.84; P = 0.01) and NAT2A803G (OR = 0.57; 95% CI = 0.33-0.97; P = 0.04) polymorphisms and PCa protection. Conversely, the presence of NAT2G857A genotype increased the risk of PCa more than 3 times (OR = 3.57; 95% CI = 1.39-9.15; P = 0.005). Slow acetylator NAT2*7A and NAT2*6B genotypes occurred in 10.31% of PCa but in none of BPH patients (P = 0.0007). The control health population confirmed the results and allowed the exclusion of possible biases caused by gender influence on genotype inheritance and by the inclusion of not diagnosed prostate diseases patients among the control individuals. We suggest that the investigation of germline polymorphisms of NAT2 gene may be useful in the assessment of Latin American patients at risk of BPH and PCa.pt
dc.relation.ispartofMedical Oncologypt_BR
dc.publisher.cityTotowapt_BR
dc.publisherHumana Press Incpt_BR
dc.date.issued2012pt_BR
dc.identifier.citationMedical Oncology. Humana Press Inc, v.29, n.4, p.2889-2894, 2012pt_BR
dc.language.isoengpt_BR
dc.description.volume29pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage2889pt_BR
dc.description.lastpage2894pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1357-0560pt_BR
dc.identifier.wosidWOS:000309711600085pt_BR
dc.identifier.doi10.1007/s12032-012-0157-4pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2013-09-19T18:06:23Z
dc.date.available2016-07-01T15:40:45Z-
dc.date.accessioned2013-09-19T18:06:23Z
dc.date.accessioned2016-07-01T15:40:45Z-
dc.description.provenanceMade available in DSpace on 2013-09-19T18:06:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2016-07-01T15:40:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2120
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2120-
dc.contributor.departmentClínica Médica
dc.contributor.unidadeFCMpt
Appears in Collections:FCM - Artigos e Outros Documentos

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