Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/2036
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleTotal Synthesis of (+)-trans-Trikentrin Apt_BR
dc.contributor.authorTebeka, Iris R. M.pt_BR
dc.contributor.authorLongato, Giovanna B.pt_BR
dc.contributor.authorCraveiro, Marcus V.pt_BR
dc.contributor.authorde Carvalho, Joao E.pt_BR
dc.contributor.authorRuiz, Ana L. T. G.pt_BR
dc.contributor.authorSilva, Luiz F., Jr.pt_BR
unicamp.authorLongato, Giovanna B.pt_BR
unicamp.authorRuiz, Ana L. T. G.pt_BR
unicamp.author.externalTebeka, Iris R. M.pt
unicamp.author.externalCraveiro, Marcus V.pt
unicamp.author.externalde Carvalho, Joao E.pt
unicamp.author.externalSilva, Luiz F., Jr.pt
dc.subjectantitumor activitypt_BR
dc.subjectkinetic resolutionpt_BR
dc.subjectring contractionpt_BR
dc.subjecttotal synthesispt_BR
dc.subjecttrikentrinpt_BR
dc.subject.wosCATALYZED ASYMMETRIC HYDROGENATIONpt_BR
dc.subject.wosMARINE NATURAL-PRODUCTSpt_BR
dc.subject.wosDIASTEREOSELECTIVE TOTAL-SYNTHESISpt_BR
dc.subject.wosPSEUDOMONAS-CEPACIA LIPASEpt_BR
dc.subject.wosRING CONTRACTION REACTIONSpt_BR
dc.subject.wosABSOLUTE-CONFIGURATIONpt_BR
dc.subject.wosSUBSTITUTED INDOLESpt_BR
dc.subject.wosESTER HOMOLOGATIONpt_BR
dc.subject.wosKINETIC RESOLUTIONpt_BR
dc.subject.wosDRUG DISCOVERYpt_BR
dc.description.abstractSeveral syntheses have already been reported for cis-trikentrins and herbindoles, which are indole alkaloids unsubstituted at the C2 and C3 positions that bear a trans-1,3-dimethylcyclopentyl unit. Herein, we describe the first asymmetric and stereoselective synthesis of the more challenging trans-trikentrin A as its naturally occurring isomer. Different approaches were investigated and the strategy of choice was a combination of an enzymatic kinetic resolution and a thallium(III)-mediated ring contraction. The antiproliferative activities of the natural product and related intermediates have been tested against human tumor cell lines, leading to the discovery of new compounds with potent antitumor activity.pt
dc.relation.ispartofChemistry-A European Journalpt_BR
dc.publisher.cityWeinheimpt_BR
dc.publisherWiley-Blackwellpt_BR
dc.date.issued2012pt_BR
dc.identifier.citationChemistry-A European Journal. Wiley-Blackwell, v.18, n.52, p.16890-16901, 2012pt_BR
dc.language.isoengpt_BR
dc.description.volume18pt_BR
dc.description.issuenumber52pt_BR
dc.description.firstpage16890pt_BR
dc.description.lastpage16901pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0947-6539pt_BR
dc.identifier.wosidWOS:000312552300031pt_BR
dc.identifier.doi10.1002/chem.201202413pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2013-09-19T18:06:17Z
dc.date.available2016-06-27T19:30:19Z-
dc.date.accessioned2013-09-19T18:06:17Z
dc.date.accessioned2016-06-27T19:30:19Z-
dc.description.provenanceMade available in DSpace on 2013-09-19T18:06:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2016-06-27T19:30:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2036
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2036-
dc.contributor.departmentFarmacologia
dc.contributor.unidadeCPQBApt
Appears in Collections:CPQBA - Artigos e Outros Documentos

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