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Type: Artigo de periódico
Title: Óxido nítrico: propriedades e potenciais usos terapêuticos
Title Alternative: Nitric oxide: properties and therapeutic use
Author: Barreto, Ricardo de L.
Correia, Carlos Roque D.
Muscará, Marcelo N.
Abstract: Nitric oxide ( NO) is a substance that acts as a second-messenger and is associated with a number of important physiological functions such as regulation of the vascular tonus, immune modulation and neurotransmission. As a physiological mediator, alteration of its concentration level may cause pathophysiological disfunctions such as hypertension, septic shock and impotence. Possible therapeutic approaches are being developed to control NO levels in vivo. We review herein the main physical and chemical properties of NO, its biological functions and available chemical interventions to reduce and increment its physiological concentration levels. Recent developments in the field are also highlighted.
Subject: nitric oxide
NOS inhibitors
Editor: Sociedade Brasileira de Química
Citation: Química Nova. Sociedade Brasileira de Química, v. 28, n. 6, p. 1046-1054, 2005.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422005000600020
Date Issue: 1-Dec-2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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