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Type: Artigo de periódico
Title: Low Molecular Weight Protein Tyrosine Phosphatase (lmwptp) Upregulation Mediates Malignant Potential In Colorectal Cancer.
Author: Hoekstra, Elmer
Kodach, Liudmila L
Das, Asha M
Ruela-de-Sousa, Roberta R
Ferreira, Carmen V
Hardwick, James C
van der Woude, C Janneke
Peppelenbosch, Maikel P
Ten Hagen, Timo L M
Fuhler, Gwenny M
Abstract: Phosphatases have long been regarded as tumor suppressors, however there is emerging evidence for a tumor initiating role for some phosphatases in several forms of cancer. Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP; acid phosphatase 1 [ACP1]) is an 18 kDa enzyme that influences the phosphorylation of signaling pathway mediators involved in cancer and is thus postulated to be a tumor-promoting enzyme, but neither unequivocal clinical evidence nor convincing mechanistic actions for a role of LMWPTP have been identified. In the present study, we show that LMWPTP expression is not only significantly increased in colorectal cancer (CRC), but also follows a step-wise increase in different levels of dysplasia. Chemical inhibition of LMWPTP significantly reduces CRC growth. Furthermore, downregulation of LMWPTP in CRC leads to a reduced migration ability in both 2D- and 3D-migration assays, and sensitizes tumor cells to the chemotherapeutic agent 5-FU. In conclusion, this study shows that LMWPTP is not only overexpressed in colorectal cancer, but it is correlated with the malignant potential of this cancer, suggesting that this phosphatase may act as a predictive biomaker of CRC stage and represents a rational novel target in the treatment of this disease.
Subject: Colorectal Cancer
Kinases And Phosphatases
Signal Transduction
Citation: Oncotarget. , 2015-Mar.
Rights: aberto
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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