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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleLymphocyte Activation In Silica-exposed Workers.pt_BR
dc.contributor.authorRocha-Parise, Michellept_BR
dc.contributor.authorSantos, Leonilda M Bpt_BR
dc.contributor.authorDamoiseaux, Jan G M Cpt_BR
dc.contributor.authorBagatin, Ericsonpt_BR
dc.contributor.authorLido, Alessandro Vpt_BR
dc.contributor.authorTorello, Cristiane Okudapt_BR
dc.contributor.authorCohen Tervaert, Jan Wpt_BR
dc.contributor.authorQueiroz, Mary L Spt_BR
unicamp.authorMichelle Rocha-Parise, Department of Pharmacology and Hemocenter, Faculty of Medical Sciences, FCM, State University of Campinas-UNICAMP, Campinas, SP, Brazil.pt_BR
unicamp.authorLeonilda M B Santos, Department of Genetics, Neuroimmunology Unit, Evolution and Bioagents, Institute of Biology, State University of Campinas-UNICAMP, Campinas, SP, Brazil.pt_BR
unicamp.authorEricson Bagatin, Department of Preventive and Social Medicine, Occupational Medicine Area, Faculty of Medical Sciences, FCM, State University of Campinas-UNICAMP, Campinas, SP, Brazil.pt_BR
unicamp.authorAlessandro V Lido, Department of Preventive and Social Medicine, Occupational Medicine Area, Faculty of Medical Sciences, FCM, State University of Campinas-UNICAMP, Campinas, SP, Brazil.pt_BR
unicamp.authorCristiane Okuda Torello, Department of Pharmacology and Hemocenter, Faculty of Medical Sciences, FCM, State University of Campinas-UNICAMP, Campinas, SP, Brazil.pt_BR
unicamp.authorMary L S Queiroz, Department of Pharmacology and Hemocenter, Faculty of Medical Sciences, FCM, State University of Campinas-UNICAMP, Campinas, SP, Brazil. Electronic address: mlsq@fcm.unicamp.br.pt_BR
unicamp.author.externalJan G M C Damoiseaux, Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.pt
unicamp.author.externalJan W Cohen Tervaert, Maastricht University, Maastricht, The Netherlandspt
unicamp.author.externalSint Franciscus Gasthuis, Rotterdam, The Netherlands.pt
dc.subjectAgedpt_BR
dc.subjectBrazilpt_BR
dc.subjectCell Proliferationpt_BR
dc.subjectEnvironmental Pollutantspt_BR
dc.subjectFemalept_BR
dc.subjectHumanspt_BR
dc.subjectInterleukin-2pt_BR
dc.subjectLeukocytes, Mononuclearpt_BR
dc.subjectLymphocyte Activationpt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectOccupational Exposurept_BR
dc.subjectReceptors, Interleukin-2pt_BR
dc.subjectSilicon Dioxidept_BR
dc.subjectAutoimmunitypt_BR
dc.subjectCytokinespt_BR
dc.subjectInterleukin-2pt_BR
dc.subjectLymphocytespt_BR
dc.subjectSilicapt_BR
dc.subjectSoluble Il-2 Receptor Alphapt_BR
dc.description.abstractExposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-γ, IL-1α, TNF-α, IL-6) as well as anti-inflammatory (IL-10 and TGF-β) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders.en
dc.relation.ispartofInternational Journal Of Hygiene And Environmental Healthpt_BR
dc.relation.ispartofabbreviationInt J Hyg Environ Healthpt_BR
dc.identifier.citationInternational Journal Of Hygiene And Environmental Health. v. 217, n. 4-5, p. 586-91pt_BR
dc.language.isoengpt_BR
dc.description.volume217pt_BR
dc.description.firstpage586-91pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2013 Elsevier GmbH. All rights reserved.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1618-131Xpt_BR
dc.identifier.doi10.1016/j.ijheh.2013.11.002pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24332681pt_BR
dc.date.available2015-11-27T13:44:00Z-
dc.date.accessioned2015-11-27T13:44:00Z-
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dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201969-
dc.identifier.idPubmed24332681pt_BR
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