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Type: Artigo de periódico
Title: Lymphocyte Activation In Silica-exposed Workers.
Author: Rocha-Parise, Michelle
Santos, Leonilda M B
Damoiseaux, Jan G M C
Bagatin, Ericson
Lido, Alessandro V
Torello, Cristiane Okuda
Cohen Tervaert, Jan W
Queiroz, Mary L S
Abstract: Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-γ, IL-1α, TNF-α, IL-6) as well as anti-inflammatory (IL-10 and TGF-β) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders.
Subject: Aged
Cell Proliferation
Environmental Pollutants
Leukocytes, Mononuclear
Lymphocyte Activation
Middle Aged
Occupational Exposure
Receptors, Interleukin-2
Silicon Dioxide
Soluble Il-2 Receptor Alpha
Citation: International Journal Of Hygiene And Environmental Health. v. 217, n. 4-5, p. 586-91
Rights: fechado
Identifier DOI: 10.1016/j.ijheh.2013.11.002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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