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Type: Artigo de periódico
Title: Disarray Of Glomerular And Tubular Cell Adhesion Molecules In The Course Of Experimental Bothrops Moojeni Envenomation.
Author: Collares-Buzato, Carla Beatriz
da Cruz-Höfling, Maria Alice
Abstract: In this study, we show that administration of Bothrops moojeni venom in rats induces a general disturbance in the distribution and content of the tight junctional protein ZO-1, the cell-matrix receptor beta 1 integrin, the cytoskeletal proteins, vinculin and F-actin, and of the extracellular matrix component laminin in renal corpuscles and cortical nephron tubules. These findings suggest that cell-cell and cell-matrix adhesion proteins may be molecular targets in the B. moojeni-induced kidney injury.
Subject: Actins
Antigens, Cd29
Cell Adhesion
Crotalid Venoms
Extracellular Matrix
Fluorescent Antibody Technique, Indirect
Kidney Glomerulus
Kidney Tubules
Snake Bites
Zonula Occludens-1 Protein
Acute Kidney Injury
Bothropic Envenomation
Cell Adhesion Proteins
Cytoskeletal Proteins
Glomerular Injury
Nephron Tubular Injury
Citation: Toxicon : Official Journal Of The International Society On Toxinology. v. 78, p. 41-6, 2014-Feb.
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2013.11.013
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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