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Type: Artigo de periódico
Title: Indole-3-carbinol Attenuates The Deleterious Gestational Effects Of Bisphenol A Exposure On The Prostate Gland Of Male F1 Rats.
Author: Brandt, Joyce Zalotti
Silveira, Lívia Teresa R
Grassi, Tony Fernando
Anselmo-Franci, Janete A
Fávaro, Wagner José
Felisbino, Sérgio Luis
Barbisan, Luis Fernando
Scarano, Wellerson Rodrigo
Abstract: Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 μg/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate.
Subject: Animals
Benzhydryl Compounds
Cell Proliferation
Endocrine Disruptors
Epithelial Cells
Estrogen Receptor Alpha
Maternal-fetal Exchange
Prenatal Exposure Delayed Effects
Protective Agents
Rats, Sprague-dawley
Receptors, Androgen
Receptors, Thrombin
Bisphenol A
Reproductive Toxicology
Citation: Reproductive Toxicology (elmsford, N.y.). v. 43, p. 56-66, 2014-Jan.
Rights: fechado
Identifier DOI: 10.1016/j.reprotox.2013.11.001
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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