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Type: Artigo de periódico
Title: Analysis Of The Contribution Of Immunologically-detectable Her2, Steroid Receptors And Of The Triple-negative" Tumor Status To Disease-free And Overall Survival Of Women With Epithelial Ovarian Cancer."
Author: de Toledo, Maria Carolina Szymanski
Sarian, Luis Otavio
Sallum, Luis Felipe
Andrade, Liliana Lucci Angelo
Vassallo, José
de Paiva Silva, Geisilene Russano
Pinto, Glauce Aparecida
Soares, Fernando Augusto
Fonseca, Camila Dal Piccolo Pracchia
Derchain, Sophie F M
Abstract: We assessed associations between steroid receptors including: estrogen-alpha, estrogen-beta, androgen receptor, progesterone receptor, the HER2 status and triple-negative epithelial ovarian cancer (ERα-/PR-/HER2-; TNEOC) status and survival in women with epithelial ovarian cancer. The study included 152 women with primary epithelial ovarian cancer. The status of steroid receptor and HER2 was determined by immunohistochemistry. Disease-free and overall survival were calculated and compared with steroid receptor and HER2 status as well as clinicopathological features using the Cox Proportional Hazards model. A mean follow-up period of 43.6 months (interquartile range=41.4 months) was achieved where 44% of patients had serous tumor, followed by mucinous (23%), endometrioid (9%), mixed (9%), undifferentiated (8.5%) and clear cell tumors (5.3%). ER-alpha staining was associated with grade II-III tumors. Progesterone receptor staining was positively associated with a Body Mass Index≥25. Androgen receptor positivity was higher in serous tumors. In stand-alone analysis of receptor contribution to survival, estrogen-alpha positivity was associated with greater disease-free survival. However, there was no significant association between steroid receptor expression, HER2 status, or TNEOC status, and overall survival. Although estrogen-alpha, androgen receptor, progesterone receptor and the HER2 status were associated with key clinical features of the women and pathological characteristics of the tumors, these associations were not implicated in survival. Interestingly, women with TNEOC seem to fare the same way as their counterparts with non-TNEOC.
Subject: Adult
Disease-free Survival
Estrogen Receptor Alpha
Estrogen Receptor Beta
Middle Aged
Neoplasms, Glandular And Epithelial
Ovarian Neoplasms
Receptor, Erbb-2
Receptors, Androgen
Receptors, Progesterone
Androgen Receptor
Estrogen Receptor
Ovarian Cancer
Progesterone Receptor
Tissue Microarray
Triple Negative
Citation: Acta Histochemica. v. 116, n. 3, p. 440-7, 2014-Apr.
Rights: fechado
Identifier DOI: 10.1016/j.acthis.2013.09.010
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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