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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAnalysis Of The Contribution Of Immunologically-detectable Her2, Steroid Receptors And Of The Triple-negative" Tumor Status To Disease-free And Overall Survival Of Women With Epithelial Ovarian Cancer."pt_BR
dc.contributor.authorde Toledo, Maria Carolina Szymanskipt_BR
dc.contributor.authorSarian, Luis Otaviopt_BR
dc.contributor.authorSallum, Luis Felipept_BR
dc.contributor.authorAndrade, Liliana Lucci Angelopt_BR
dc.contributor.authorVassallo, Josépt_BR
dc.contributor.authorde Paiva Silva, Geisilene Russanopt_BR
dc.contributor.authorPinto, Glauce Aparecidapt_BR
dc.contributor.authorSoares, Fernando Augustopt_BR
dc.contributor.authorFonseca, Camila Dal Piccolo Pracchiapt_BR
dc.contributor.authorDerchain, Sophie F Mpt_BR
unicamp.authorMaria Carolina Szymanski de Toledo, Department of Obstetrics and Gynecology, Faculty of Medical Sciences, State University of Campinas - Unicamp, Campinas, São Paulo, Brazil.pt_BR
unicamp.authorLuis Otavio Sarian, Department of Obstetrics and Gynecology, Faculty of Medical Sciences, State University of Campinas - Unicamp, Campinas, São Paulo, Brazil. Electronic address: sarian@unicamp.br.pt_BR
unicamp.authorLuis Felipe Sallum, Department of Obstetrics and Gynecology, Faculty of Medical Sciences, State University of Campinas - Unicamp, Campinas, São Paulo, Brazil.pt_BR
unicamp.authorLiliana Lucci Angelo Andrade, Department of Pathology, Faculty of Medical Sciences, State University of Campinas - Unicamp, Campinas, São Paulo, Brazil.pt_BR
unicamp.authorJosé Vassallo, Laboratory of Experimental Pathology, CAISM - Unicamp, Campinas, São Paulo, Brazil.pt_BR
unicamp.authorGeisilene Russano de Paiva Silva, Department of Pathology, Faculty of Medical Sciences, State University of Campinas - Unicamp, Campinas, São Paulo, Brazilpt_BR
unicamp.authorLaboratory of Experimental Pathology, CAISM - Unicamp, Campinas, São Paulo, Brazil.pt_BR
unicamp.authorGlauce Aparecida Pinto, Laboratory of Experimental Pathology, CAISM - Unicamp, Campinas, São Paulo, Brazil.pt_BR
unicamp.authorCamila Dal Piccolo Pracchia Fonseca, Department of Obstetrics and Gynecology, Faculty of Medical Sciences, State University of Campinas - Unicamp, Campinas, São Paulo, Brazil.pt_BR
unicamp.authorSophie F M Derchain, Department of Obstetrics and Gynecology, Faculty of Medical Sciences, State University of Campinas - Unicamp, Campinas, São Paulo, Brazil.pt_BR
unicamp.author.externalFernando Augusto Soares, Department of Pathology, Hospital do Câncer A C Camargo, Fundação Antonio Prudente de São Paulo, Brazil.pt
dc.subjectAdultpt_BR
dc.subjectAgedpt_BR
dc.subjectDisease-free Survivalpt_BR
dc.subjectEstrogen Receptor Alphapt_BR
dc.subjectEstrogen Receptor Betapt_BR
dc.subjectFemalept_BR
dc.subjectHumanspt_BR
dc.subjectMiddle Agedpt_BR
dc.subjectNeoplasms, Glandular And Epithelialpt_BR
dc.subjectOvarian Neoplasmspt_BR
dc.subjectReceptor, Erbb-2pt_BR
dc.subjectReceptors, Androgenpt_BR
dc.subjectReceptors, Progesteronept_BR
dc.subjectAndrogen Receptorpt_BR
dc.subjectEstrogen Receptorpt_BR
dc.subjectHer2pt_BR
dc.subjectOvarian Cancerpt_BR
dc.subjectProgesterone Receptorpt_BR
dc.subjectTissue Microarraypt_BR
dc.subjectTriple Negativept_BR
dc.description.abstractWe assessed associations between steroid receptors including: estrogen-alpha, estrogen-beta, androgen receptor, progesterone receptor, the HER2 status and triple-negative epithelial ovarian cancer (ERα-/PR-/HER2-; TNEOC) status and survival in women with epithelial ovarian cancer. The study included 152 women with primary epithelial ovarian cancer. The status of steroid receptor and HER2 was determined by immunohistochemistry. Disease-free and overall survival were calculated and compared with steroid receptor and HER2 status as well as clinicopathological features using the Cox Proportional Hazards model. A mean follow-up period of 43.6 months (interquartile range=41.4 months) was achieved where 44% of patients had serous tumor, followed by mucinous (23%), endometrioid (9%), mixed (9%), undifferentiated (8.5%) and clear cell tumors (5.3%). ER-alpha staining was associated with grade II-III tumors. Progesterone receptor staining was positively associated with a Body Mass Index≥25. Androgen receptor positivity was higher in serous tumors. In stand-alone analysis of receptor contribution to survival, estrogen-alpha positivity was associated with greater disease-free survival. However, there was no significant association between steroid receptor expression, HER2 status, or TNEOC status, and overall survival. Although estrogen-alpha, androgen receptor, progesterone receptor and the HER2 status were associated with key clinical features of the women and pathological characteristics of the tumors, these associations were not implicated in survival. Interestingly, women with TNEOC seem to fare the same way as their counterparts with non-TNEOC.en
dc.relation.ispartofActa Histochemicapt_BR
dc.relation.ispartofabbreviationActa Histochem.pt_BR
dc.date.issued2014-Aprpt_BR
dc.identifier.citationActa Histochemica. v. 116, n. 3, p. 440-7, 2014-Apr.pt_BR
dc.language.isoengpt_BR
dc.description.volume116pt_BR
dc.description.firstpage440-7pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2013 Elsevier GmbH. All rights reserved.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1618-0372pt_BR
dc.identifier.doi10.1016/j.acthis.2013.09.010pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24238473pt_BR
dc.date.available2015-11-27T13:43:21Z-
dc.date.accessioned2015-11-27T13:43:21Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:43:21Z (GMT). No. of bitstreams: 1 pmed_24238473.pdf: 1788361 bytes, checksum: dae73d8d2ea7a79e055b53a044ff18d1 (MD5) Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201716-
dc.identifier.idPubmed24238473pt_BR
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