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Type: Artigo de periódico
Title: Treadmill Training Increases Sirt-1 And Pgc-1 α Protein Levels And Ampk Phosphorylation In Quadriceps Of Middle-aged Rats In An Intensity-dependent Manner.
Author: Oliveira, Nara R C
Marques, Scherolin O
Luciano, Thais F
Pauli, José R
Moura, Leandro P
Caperuto, Erico
Pieri, Bruno L S
Engelmann, Julia
Scaini, Gisele
Streck, Emilio L
Lira, Fabio S
Pinho, Ricardo A
Ropelle, Eduardo R
Silva, Adelino S R
De Souza, Cláudio T
Abstract: The present study investigated the effects of running at 0.8 or 1.2 km/h on inflammatory proteins (i.e., protein levels of TNF- α , IL-1 β , and NF- κ B) and metabolic proteins (i.e., protein levels of SIRT-1 and PGC-1 α , and AMPK phosphorylation) in quadriceps of rats. Male Wistar rats at 3 (young) and 18 months (middle-aged rats) of age were divided into nonexercised (NE) and exercised at 0.8 or 1.2 km/h. The rats were trained on treadmill, 50 min per day, 5 days per week, during 8 weeks. Forty-eight hours after the last training session, muscles were removed, homogenized, and analyzed using biochemical and western blot techniques. Our results showed that: (a) running at 0.8 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with NE rats; (b) these responses were lower for the inflammatory proteins and higher for the metabolic proteins in young rats compared with middle-aged rats; (c) running at 1.2 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with 0.8 km/h; (d) these responses were similar between young and middle-aged rats when trained at 1.2 km. In summary, the age-related increases in inflammatory proteins, and the age-related declines in metabolic proteins can be reversed and largely improved by treadmill training.
Subject: Amp-activated Protein Kinases
Muscle, Skeletal
Physical Conditioning, Animal
Rats, Wistar
Sirtuin 1
Transcription Factors
Citation: Mediators Of Inflammation. v. 2014, p. 987017, 2014.
Rights: aberto
Identifier DOI: 10.1155/2014/987017
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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