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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleObesity And Thyroid Cancer.pt_BR
dc.contributor.authorMarcello, Marjory Alanapt_BR
dc.contributor.authorCunha, Lucas Leitept_BR
dc.contributor.authorBatista, Fernando Assispt_BR
dc.contributor.authorWard, Laura Sterianpt_BR
unicamp.authorMarjory Alana Marcello, Laboratory of Cancer Molecular Genetics (Gemoca)Faculty of Medical Sciences, University of Campinas (FCM- Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo 13083-970, Brazil marjoryam@gmail.com.pt_BR
unicamp.authorLucas Leite Cunha, Laboratory of Cancer Molecular Genetics (Gemoca)Faculty of Medical Sciences, University of Campinas (FCM- Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo 13083-970, Brazil.pt_BR
unicamp.authorFernando Assis Batista, Laboratory of Cancer Molecular Genetics (Gemoca)Faculty of Medical Sciences, University of Campinas (FCM- Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo 13083-970, Brazil.pt_BR
unicamp.authorLaura Sterian Ward, Laboratory of Cancer Molecular Genetics (Gemoca)Faculty of Medical Sciences, University of Campinas (FCM- Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo 13083-970, Brazil.pt_BR
dc.subjectMolecular Biologypt_BR
dc.subjectObesitypt_BR
dc.subjectOncologypt_BR
dc.description.abstractMany studies have provided observational data on the association of obesity and thyroid cancers, but only few of them propose mechanisms that would permit a better understanding of the causal molecular mechanisms of this association. Considering that there is an increasing incidence of both obesity and thyroid cancers, we need to summarize and link recent studies in order to characterize and understand the contribution of obesity-related factors that might affect thyroid cancer development and progression. Adipose tissue is involved in many vital processes, including insulin sensitivity, angiogenesis, regulation of energy balance, activation of the complement system, and responses such as inflammation. Although these processes have their own molecular pathways, they involve the same molecules through which obesity and adipose tissue might exert their roles in carcinogenesis, not only affecting MAPK and PI3K or even insulin pathways, but also recruiting local inflammatory responses that could result in disease formation and progression. This review describes five important issues that might explain the link between excessive weight and thyroid cancer: thyroid hormones, insulin resistance, adipokines, inflammation, and sexual hormones.en
dc.relation.ispartofEndocrine-related Cancerpt_BR
dc.relation.ispartofabbreviationEndocr. Relat. Cancerpt_BR
dc.date.issued2014-Octpt_BR
dc.identifier.citationEndocrine-related Cancer. v. 21, n. 5, p. T255-71, 2014-Oct.pt_BR
dc.language.isoengpt_BR
dc.description.volume21pt_BR
dc.description.firstpageT255-71pt_BR
dc.rightsfechadopt_BR
dc.rights.holder© 2014 Society for Endocrinology.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1479-6821pt_BR
dc.identifier.doi10.1530/ERC-14-0070pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24741026pt_BR
dc.date.available2015-11-27T13:42:22Z-
dc.date.accessioned2015-11-27T13:42:22Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:42:22Z (GMT). No. of bitstreams: 1 pmed_24741026.pdf: 467437 bytes, checksum: 5f9f2ad23e02409f2815123fd9aa02a7 (MD5) Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201330-
dc.identifier.idPubmed24741026pt_BR
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