Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Ankhd1, A Novel Component Of The Hippo Signaling Pathway, Promotes Yap1 Activation And Cell Cycle Progression In Prostate Cancer Cells.
Author: Machado-Neto, João Agostinho
Lazarini, Mariana
Favaro, Patricia
Franchi, Gilberto Carlos
Nowill, Alexandre Eduardo
Saad, Sara Teresinha Olalla
Traina, Fabiola
Abstract: ANKHD1 is a multiple ankyrin repeat containing protein, recently identified as a novel member of the Hippo signaling pathway. The present study aimed to investigate the role of ANKHD1 in DU145 and LNCaP prostate cancer cells. ANKHD1 and YAP1 were found to be highly expressed in prostate cancer cells, and ANKHD1 silencing decreased cell growth, delayed cell cycle progression at the S phase, and reduced tumor xenograft growth. Moreover, ANKHD1 knockdown downregulated YAP1 expression and activation, and reduced the expression of CCNA2, a YAP1 target gene. These findings indicate that ANKHD1 is a positive regulator of YAP1 and promotes cell growth and cell cycle progression through Cyclin A upregulation.
Subject: Adaptor Proteins, Signal Transducing
Cell Cycle
Cell Line, Tumor
Cyclin A
Gene Expression Regulation, Neoplastic
Hela Cells
K562 Cells
Mice, Inbred Nod
Mice, Scid
Mice, Transgenic
Prostatic Neoplasms
Protein-serine-threonine Kinases
Rna-binding Proteins
Signal Transduction
Transcriptional Activation
Cell Cycle
Hippo Pathway
Prostate Cancer
Citation: Experimental Cell Research. v. 324, n. 2, p. 137-45, 2014-Jun.
Rights: fechado
Identifier DOI: 10.1016/j.yexcr.2014.04.004
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_24726915.pdf4.15 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.