Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201149
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.title gstt1, Gstm1, And Gstp1 Polymorphisms As A Prognostic Factor In Women With Breast Cancer.pt_BR
dc.contributor.authorOliveira, A Lpt_BR
dc.contributor.authorOliveira Rodrigues, F Fpt_BR
dc.contributor.authorDos Santos, R Ept_BR
dc.contributor.authorRozenowicz, R Lpt_BR
dc.contributor.authorBarbosa de Melo, Mpt_BR
unicamp.authorM Barbosa de Melo, Laboratório de Genética Molecular Humana, Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas, Campinas, SP, Brasil.pt_BR
unicamp.author.externalA L Oliveira, Departamento de Obstetrícia e Ginecologia, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil drandrel@terra.com.br.pt
unicamp.author.externalF F Oliveira Rodrigues, Departamento de Obstetrícia e Ginecologia, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.pt
unicamp.author.externalR E Dos Santos, Departamento de Obstetrícia e Ginecologia, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.pt
unicamp.author.externalR L Rozenowicz, Departamento de Obstetrícia e Ginecologia, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.pt
dc.subjectAdultpt_BR
dc.subjectAgedpt_BR
dc.subjectAntineoplastic Agentspt_BR
dc.subjectBreast Neoplasmspt_BR
dc.subjectDisease-free Survivalpt_BR
dc.subjectFemalept_BR
dc.subjectGenetic Predisposition To Diseasept_BR
dc.subjectGenotypept_BR
dc.subjectGlutathione S-transferase Pipt_BR
dc.subjectGlutathione Transferasept_BR
dc.subjectHumanspt_BR
dc.subjectLymph Nodespt_BR
dc.subjectMiddle Agedpt_BR
dc.subjectPolymorphism, Single Nucleotidept_BR
dc.subjectPrognosispt_BR
dc.description.abstractThe glutathione S-transferase (GST) family comprises phase-II cellular detoxification enzymes that catalyze the conjugation of chemotherapy drugs to glutathione and act on the apoptotic pathway. The aim of this study was to determine whether polymorphisms of the GSTT1, GSTM1, and GSTP1 genes are associated with different rates of overall survival (OS) and disease-free survival (DFS) after neoadjuvant chemotherapy in the management of locally advanced breast cancer, using either simple or combined analyses, and in relation to the post-therapy axillary lymph node status. Forty women with invasive ductal carcinoma of the breast submitted to neoadjuvant chemotherapy with 5-fluorouracil, epirubicin, and cyclophosphamide were genotyped for GSTT1, GSTM1, and GSTP1. Comparisons were performed for the three genes, either isolated or in pairs, in polymorphic or wild-type combinations. Finally, the OS and DFS of patients were analyzed with respect to axillary lymph node status and with respect to wild-type or polymorphic presentations of each gene. No statistically significant difference in OS and DFS was evident between women with wild-type or polymorphic forms of the genes, either isolated or in pairs, after neoadjuvant chemotherapy. By contrast, after treatment, lymph node-negative women had better OS and DFS only in the presence of polymorphisms of GSTP1, and improved DFS only in the presence of the polymorphic types of GSTT1 and GSTM1 compared to women with positive lymph nodes. The presence of polymorphic forms of GSTP1, GSTM1, and GSTT1 was crucial to conferring better OS and DFS among women with negative axillary lymph nodes.en
dc.relation.ispartofGenetics And Molecular Research : Gmrpt_BR
dc.relation.ispartofabbreviationGenet. Mol. Res.pt_BR
dc.date.issued2014pt_BR
dc.identifier.citationGenetics And Molecular Research : Gmr. v. 13, n. 2, p. 2521-30, 2014.pt_BR
dc.language.isoengpt_BR
dc.description.volume13pt_BR
dc.description.firstpage2521-30pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1676-5680pt_BR
dc.identifier.doi10.4238/2014.January.22.9pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24535908pt_BR
dc.date.available2015-11-27T13:41:56Z-
dc.date.accessioned2015-11-27T13:41:56Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:41:56Z (GMT). No. of bitstreams: 1 pmed_24535908.pdf: 721052 bytes, checksum: 51a33ce59ecc892f0d5067e420f9664f (MD5) Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201149-
dc.identifier.idPubmed24535908pt_BR
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