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Type: Artigo de periódico
Title: Expression Of Prox-1 In Oral Kaposi's Sarcoma Spindle Cells.
Author: Benevenuto de Andrade, Bruno Augusto
Ramírez-Amador, Velia
Anaya-Saavedra, Gabriela
Martínez-Mata, Guillermo
Fonseca, Felipe P
Graner, Edgard
Paes de Almeida, Oslei
Abstract: The histogenesis of neoplastic spindle cells of Kaposi's sarcoma is still uncertain, but some studies consider it a lymphatic vessel differentiation. Prox-1 is a nuclear transcription factor that plays a major role during embryonic lymphangiogenesis, and it has been considered a specific and sensitive lymphatic endothelial cell marker. The aim of this study was to determine the expression of Prox-1 in oral Kaposi's sarcoma comparing the results with oral benign vascular tumors including capillary hemangiomas and pyogenic granulomas. Expression of Prox-1 and HHV-8 was evaluated by immunohistochemistry in 30 oral Kaposi's sarcoma, 5 oral capillary hemangiomas, and 10 oral pyogenic granulomas. The labeling index was expressed as the percentage of positive cells for each case studied. Statistical comparison was performed using the Wilcoxon-Mann-Whitney rank sum test. Twenty-eight (93.3%) and 30 oral Kaposi's sarcoma cases were positive for Prox-1 and HHV-8, respectively, while all oral benign vascular tumors were negative for these markers. The number of Prox-1 and HHV-8 oral Kaposi's sarcoma-positive cells increased significantly from patch/plaque to nodular histological stages. The expression of Prox-1 in the neoplastic spindle cells supports the view of a lymphatic differentiation in oral Kaposi's sarcoma. Prox-1 may also be involved in the pathogenesis of oral Kaposi's sarcoma as the number of positive spindle cells increased progressively from patch to nodular stages and could be eventually useful as an additional diagnostic tool for differential diagnosis between oral Kaposi's sarcoma and benign oral vascular lesions.
Subject: Adolescent
Cell Differentiation
Cell Proliferation
Endothelium, Lymphatic
Gingival Diseases
Granuloma, Pyogenic
Hiv Seropositivity
Hemangioma, Capillary
Herpesvirus 8, Human
Homeodomain Proteins
Middle Aged
Mouth Neoplasms
Sarcoma, Kaposi
Tongue Diseases
Tongue Neoplasms
Tumor Markers, Biological
Tumor Suppressor Proteins
Young Adult
Oral Kaposi's Sarcoma
Citation: Journal Of Oral Pathology & Medicine : Official Publication Of The International Association Of Oral Pathologists And The American Academy Of Oral Pathology. v. 43, n. 2, p. 132-6, 2014-Feb.
Rights: fechado
Identifier DOI: 10.1111/jop.12097
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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