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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCigarette Smoke Inhalation Increases The Alveolar Bone Loss Caused By Primary Occlusal Trauma In A Rat Model.pt_BR
dc.contributor.authorCampos, M L Gpt_BR
dc.contributor.authorCorrêa, M Gpt_BR
dc.contributor.authorJúnior, F H Npt_BR
dc.contributor.authorCasati, M Zpt_BR
dc.contributor.authorSallum, E Apt_BR
dc.contributor.authorSallum, A Wpt_BR
unicamp.authorM L G Campos, Department of Prosthodontics and Periodontics, Division of Periodontics, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, Brazil.pt_BR
unicamp.author.externalM G Corrêa,pt
unicamp.author.externalF H N Júnior,pt
unicamp.author.externalM Z Casati,pt
unicamp.author.externalE A Sallum,pt
unicamp.author.externalA W Sallum,pt
dc.subjectAlveolar Bone Losspt_BR
dc.subjectCigarette Smokingpt_BR
dc.subjectRatspt_BR
dc.subjectTraumatic Dental Occlusionpt_BR
dc.description.abstractOcclusal trauma (OT) and smoking are both factors that alter alveolar bone metabolism and therefore could synergistically act on alveolar bone loss. The aim of this experimental study was to evaluate the influence of short-term cigarette smoke inhalation (CSI) on inter-radicular alveolar bone loss promoted by primary OT in a rat model. Forty-eight animals were randomly assigned to one of three groups based on treatment type: OT + CSI (n = 16), animals were exposed to CSI three times per day, for 8 min per exposure, and they concomitantly received unilateral vertical augmentation creating an occlusal interference inducing experimental OT; OT (n = 16), animals received only unilateral vertical augmentation; negative control (NC; n = 16), animals maintained for equal periods to achieve periodontal baseline values of periodontal ligament dimension. Each group was divided into two subgroups (n = 8) based on treatment length: 7 or 14 d. After 7 d, the OT + CSI group exhibited significantly higher bone loss compared to the NC group (p = 0.0022). After 14 d, the OT (p < 0.0001) and OT + CSI (p < 0.0001) groups presented significantly higher bone loss compared to the NC group, and OT + CSI resulted in significantly higher bone loss than OT alone (p = 0.0241). The number of tartrate-resistant acid phosphatase-positive cells on the linear surface of the bone crest after 7 d was significantly higher in the OT + CSI group as compared to the NC and OT groups (p < 0.0001 and p = 0.0045, respectively) and remained significantly higher in the OT + CSI group after 14 d, compared to the OT group (p < 0.0001). Short-term CSI increases early bone loss in association with OT after 7 d, and this worsens in severity after 14 d of exposure.en
dc.relation.ispartofJournal Of Periodontal Researchpt_BR
dc.relation.ispartofabbreviationJ. Periodont. Res.pt_BR
dc.date.issued2014-Aprpt_BR
dc.identifier.citationJournal Of Periodontal Research. v. 49, n. 2, p. 179-85, 2014-Apr.pt_BR
dc.language.isoengpt_BR
dc.description.volume49pt_BR
dc.description.firstpage179-85pt_BR
dc.rightsfechadopt_BR
dc.rights.holder© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1600-0765pt_BR
dc.identifier.doi10.1111/jre.12091pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23679047pt_BR
dc.date.available2015-11-27T13:41:38Z-
dc.date.accessioned2015-11-27T13:41:38Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:41:38Z (GMT). No. of bitstreams: 1 pmed_23679047.pdf: 486861 bytes, checksum: 5b1db63776a9f7d61e3c6bc9b9066869 (MD5) Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201045-
dc.identifier.idPubmed23679047pt_BR
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