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dc.typeArtigo de periódicopt_BR
dc.titleNeuropsychiatric Symptoms In Alzheimer's Disease Are Related To Functional Connectivity Alterations In The Salience Network.pt_BR
dc.contributor.authorBalthazar, Marcio L Fpt_BR
dc.contributor.authorPereira, Fabrício R Spt_BR
dc.contributor.authorLopes, Tátila Mpt_BR
dc.contributor.authorda Silva, Elvis Lpt_BR
dc.contributor.authorCoan, Ana Carolinapt_BR
dc.contributor.authorCampos, Brunno Mpt_BR
dc.contributor.authorDuncan, Niall Wpt_BR
dc.contributor.authorStella, Florindopt_BR
dc.contributor.authorNorthoff, Georgpt_BR
dc.contributor.authorDamasceno, Benito Ppt_BR
dc.contributor.authorCendes, Fernandopt_BR
unicamp.authorMarcio L F Balthazar, Neuroimaging Laboratory, Department of Neurology, Medical Sciences School, University of Campinas (UNICAMP), Brazil.pt_BRício R S Pereira,ptátila M Lopes,pt L da Silva,pt Carolina Coan,pt M Campos,pt W Duncan,pt Stella,pt Northoff,pt P Damasceno,pt Cendes,pt
dc.subjectAlzheimer Diseasept_BR
dc.subjectBrain Mappingpt_BR
dc.subjectMagnetic Resonance Imagingpt_BR
dc.subjectNerve Fibers, Unmyelinatedpt_BR
dc.subjectNeural Pathwayspt_BR
dc.subjectNeuropsychological Testspt_BR
dc.subjectPsychiatric Status Rating Scalespt_BR
dc.subjectRegression Analysispt_BR
dc.subjectAlzheimer's Diseasept_BR
dc.subjectDefault Mode Networkpt_BR
dc.subjectFunctional Connectivitypt_BR
dc.subjectNeuropsychiatric Symptomspt_BR
dc.subjectSalience Networkpt_BR
dc.description.abstractNeuropsychiatric syndromes are highly prevalent in Alzheimer's disease (AD), but their neurobiology is not completely understood. New methods in functional magnetic resonance imaging, such as intrinsic functional connectivity or resting-state analysis, may help to clarify this issue. Using such approaches, alterations in the default-mode and salience networks (SNs) have been described in Alzheimer's, although their relationship with specific symptoms remains unclear. We therefore carried out resting-state functional connectivity analysis with 20 patients with mild to moderate AD, and correlated their scores on neuropsychiatric inventory syndromes (apathy, hyperactivity, affective syndrome, and psychosis) with maps of connectivity in the default mode network and SN. In addition, we compared network connectivity in these patients with that in 17 healthy elderly control subjects. All analyses were controlled for gray matter density and other potential confounds. Alzheimer's patients showed increased functional connectivity within the SN compared with controls (right anterior cingulate cortex and left medial frontal gyrus), along with reduced functional connectivity in the default-mode network (bilateral precuneus). A correlation between increased connectivity in anterior cingulate cortex and right insula areas of the SN and hyperactivity syndrome (agitation, irritability, aberrant motor behavior, euphoria, and disinhibition) was found. These findings demonstrate an association between specific network changes in AD and particular neuropsychiatric symptom types. This underlines the potential clinical significance of resting state alterations in future diagnosis and therapy.en
dc.relation.ispartofHuman Brain Mappingpt_BR
dc.relation.ispartofabbreviationHum Brain Mapppt_BR
dc.identifier.citationHuman Brain Mapping. v. 35, n. 4, p. 1237-46, 2014-Apr.pt_BR
dc.rights.holderCopyright © 2013 Wiley Periodicals, Inc.pt_BR
dc.description.provenanceMade available in DSpace on 2015-11-27T13:41:37Z (GMT). No. of bitstreams: 1 pmed_23418130.pdf: 295341 bytes, checksum: 2e988789429d0d52e229e81902603d04 (MD5) Previous issue date: 2014en
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