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Type: Artigo de periódico
Title: Second Harmonic Generation Microscopy As A Powerful Diagnostic Imaging Modality For Human Ovarian Cancer.
Author: Adur, Javier
Pelegati, Vitor B
de Thomaz, Andre A
Baratti, Mariana O
Andrade, Liliana A L A
Carvalho, Hernandes F
Bottcher-Luiz, Fátima
Cesar, Carlos Lenz
Abstract: In this study we showed that second-harmonic generation (SHG) microscopy combined with precise methods for images evaluation can be used to detect structural changes in the human ovarian stroma. Using a set of scoring methods (alignment of collagen fibers, anisotropy, and correlation), we found significant differences in the distribution and organization of collagen fibers in the stroma component of serous, mucinous, endometrioid and mixed ovarian tumors as compared with normal ovary tissue. This methodology was capable to differentiate between cancerous and healthy tissue, with clear cut distinction between normal, benign, borderline, and malignant tumors of serous type. Our results indicated that the combination of different image-analysis approaches presented here represent a powerful tool to investigate collagen organization and extracellular matrix remodeling in ovarian tumors.
Subject: Collagen
Diagnostic Imaging
Ovarian Neoplasms
Collagen Quantification
Extracellular Matrix
Ovarian Epithelial Tumors
Second-harmonic Generation Microscopy
Citation: Journal Of Biophotonics. v. 7, n. 1-2, p. 37-48, 2014-Jan.
Rights: fechado
Identifier DOI: 10.1002/jbio.201200108
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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