Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/201019
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleArhgap21 Protein, A New Partner Of α-tubulin Involved In Cell-cell Adhesion Formation And Essential For Epithelial-mesenchymal Transition.pt_BR
dc.contributor.authorBarcellos, Karin S Apt_BR
dc.contributor.authorBigarella, Carolina Lpt_BR
dc.contributor.authorWagner, Mark Vpt_BR
dc.contributor.authorVieira, Karla Ppt_BR
dc.contributor.authorLazarini, Marianapt_BR
dc.contributor.authorLangford, Peter Rpt_BR
dc.contributor.authorMachado-Neto, João Apt_BR
dc.contributor.authorCall, Steven Gpt_BR
dc.contributor.authorStaley, Davis Mpt_BR
dc.contributor.authorChung, Jarom Ypt_BR
dc.contributor.authorHansen, Marc Dpt_BR
dc.contributor.authorSaad, Sara T Opt_BR
unicamp.authorKarin S A Barcellos, Hematology and Hemotherapy Center, University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, São Paulo, 13083-970, Brazil.pt_BR
unicamp.author.externalCarolina L Bigarella,pt
unicamp.author.externalMark V Wagner,pt
unicamp.author.externalKarla P Vieira,pt
unicamp.author.externalMariana Lazarini,pt
unicamp.author.externalPeter R Langford,pt
unicamp.author.externalJoão A Machado-Neto,pt
unicamp.author.externalSteven G Call,pt
unicamp.author.externalDavis M Staley,pt
unicamp.author.externalJarom Y Chung,pt
unicamp.author.externalMarc D Hansen,pt
unicamp.author.externalSara T O Saad,pt
dc.subjectAcetylationpt_BR
dc.subjectAnimalspt_BR
dc.subjectCell Adhesionpt_BR
dc.subjectCell Communicationpt_BR
dc.subjectCell Line, Tumorpt_BR
dc.subjectCell Movementpt_BR
dc.subjectDogspt_BR
dc.subjectEpithelial-mesenchymal Transitionpt_BR
dc.subjectEpitheliumpt_BR
dc.subjectGtpase-activating Proteinspt_BR
dc.subjectHumanspt_BR
dc.subjectMadin Darby Canine Kidney Cellspt_BR
dc.subjectNeoplasm Metastasispt_BR
dc.subjectRna Interferencept_BR
dc.subjectTime Factorspt_BR
dc.subjectTubulinpt_BR
dc.subjectCdc42 Gtp-binding Proteinpt_BR
dc.description.abstractCell-cell adhesions and the cytoskeletons play important and coordinated roles in cell biology, including cell differentiation, development, and migration. Adhesion and cytoskeletal dynamics are regulated by Rho-GTPases. ARHGAP21 is a negative regulator of Rho-GTPases, particularly Cdc42. Here we assess the function of ARHGAP21 in cell-cell adhesion, cell migration, and scattering. We find that ARHGAP21 is localized in the nucleus, cytoplasm, or perinuclear region but is transiently redistributed to cell-cell junctions 4 h after initiation of cell-cell adhesion. ARHGAP21 interacts with Cdc42, and decreased Cdc42 activity coincides with the appearance of ARHGAP21 at the cell-cell junctions. Cells lacking ARHGAP21 expression show weaker cell-cell adhesions, increased cell migration, and a diminished ability to undergo hepatocyte growth factor-induced epithelial-mesenchymal transition (EMT). In addition, ARHGAP21 interacts with α-tubulin, and it is essential for α-tubulin acetylation in EMT. Our findings indicate that ARHGAP21 is a Rho-GAP involved in cell-cell junction remodeling and that ARHGAP21 affects migration and EMT through α-tubulin interaction and acetylation.en
dc.relation.ispartofThe Journal Of Biological Chemistrypt_BR
dc.relation.ispartofabbreviationJ. Biol. Chem.pt_BR
dc.date.issued2013-Janpt_BR
dc.identifier.citationThe Journal Of Biological Chemistry. v. 288, n. 4, p. 2179-89, 2013-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume288pt_BR
dc.description.firstpage2179-89pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1083-351Xpt_BR
dc.identifier.doi10.1074/jbc.M112.432716pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23235160pt_BR
dc.date.available2015-11-27T13:32:38Z-
dc.date.accessioned2015-11-27T13:32:38Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:32:38Z (GMT). No. of bitstreams: 1 pmed_23235160.pdf: 5128597 bytes, checksum: 13168041cee80c3c32f8955f6f512542 (MD5) Previous issue date: 2013en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201019-
dc.identifier.idPubmed23235160pt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_23235160.pdf5.01 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.