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Type: Artigo de periódico
Title: Appetite-regulating Hormones From The Upper Gut: Disrupted Control Of Xenin And Ghrelin In Night Workers.
Author: Schiavo-Cardozo, Daniela
Lima, Marcelo M O
Pareja, José Carlos
Geloneze, Bruno
Abstract: Shift work is associated with circadian rhythm disorder, impaired sleep and behavioural changes, including eating habits, predisposing to obesity and metabolic dysfunctions. It involves a neuro-hormonal dysregulation of appetite towards positive energy balance, including increased ghrelin and decreased leptin, but little is known about other hormones, such as xenin, derived from the upper gut (like ghrelin), and lower gut hormones. Our objective was to compare night workers with day workers in relation to appetite-regulating hormones and other metabolic parameters. Cross-sectional, observational study. Twenty-four overweight women, divided into night shift workers (n = 12) and day shift workers (n = 12). BMI, waist circumference, fat mass percentage; diet composition; Pittsburgh Sleep Quality Index; lipids; adipokines; meal tolerance test curves of glucose, insulin, ghrelin, PYY3-36, oxyntomodulin, xenin, GLP-1; insulin sensitivity (Stumvoll index). Night workers, as compared with day workers, had greater body fat mass percentage and tendency to greater waist circumference despite similar BMI; greater energy intake; impaired sleep; lower insulin sensitivity; increased triglycerides and tendency to increased C-reactive protein; similar levels of leptin and other adipokines. Night workers had a blunted post-meal suppression of ghrelin (AUCi(0-60 min) 19·4 ± 139·9 vs -141·9 ± 9·0 ng/ml·60 min, P < 0·01); blunted rise of xenin (AUC(0-180 min) 8690·9 ± 2988·2 vs 28 504·4 ± 20 308·3 pg/ml·180 min, P < 0·01) and similar curves of PYY3-36, oxyntomodulin and GPL-1. Compared with day workers within the same BMI range, night workers presented a disrupted control of ghrelin and xenin, associated with behavioural changes in diet and sleep and increased adiposity and related metabolic alterations.
Subject: Adiposity
Appetite Regulation
Cross-sectional Studies
Digestive System
Energy Intake
Gastrointestinal Hormones
Glucagon-like Peptide 1
Insulin Resistance
Peptide Fragments
Peptide Yy
Sleep Disorders, Circadian Rhythm
Work Schedule Tolerance
Citation: Clinical Endocrinology. v. 79, n. 6, p. 807-11, 2013-Dec.
Rights: fechado
Identifier DOI: 10.1111/cen.12114
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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