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dc.typeArtigo de periódicopt_BR
dc.titleHla Markers For Poor Prognosis In Systemic Sclerosis Brazilian Patients.pt_BR
dc.contributor.authorDel Rio, Ana Paula Toledopt_BR
dc.contributor.authorSachetto, Zoraidapt_BR
dc.contributor.authorSampaio-Barros, Percival Degravapt_BR
dc.contributor.authorMarques-Neto, João Franciscopt_BR
dc.contributor.authorLonde, Ana Carolina Santospt_BR
dc.contributor.authorBertolo, Manoel Barrospt_BR
unicamp.authorAna Paula Toledo Del Rio, Unit of Rheumatology, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.pt_BR Sachetto,pt Degrava Sampaio-Barros,ptão Francisco Marques-Neto,pt Carolina Santos Londe,pt Barros Bertolo,pt
dc.subjectFamilial Primary Pulmonary Hypertensionpt_BR
dc.subjectGene Frequencypt_BR
dc.subjectGenetic Association Studiespt_BR
dc.subjectGenetic Markerspt_BR
dc.subjectHla-a Antigenspt_BR
dc.subjectHla-b Antigenspt_BR
dc.subjectHla-c Antigenspt_BR
dc.subjectHla-dq Beta-chainspt_BR
dc.subjectHla-drb1 Chainspt_BR
dc.subjectHypertension, Pulmonarypt_BR
dc.subjectPulmonary Fibrosispt_BR
dc.subjectScleroderma, Systemicpt_BR
dc.description.abstractThe aim of this study was to evaluate human leukocyte antigen (HLA) involvement in the disease expression and poor prognostic clinical features (pulmonary fibrosis and pulmonary arterial hypertension) in patients diagnosed with systemic sclerosis (SSc) in a multiethnic population. SSc patients followed up between 2008 and 2011 were included, and clinical data were obtained through records review. Molecular HLA typing was performed (polymerase chain reaction amplification technique using specific primer sequences). The statistical analysis involved Fisher's exact test and Pearson's corrected chi-square test. P (values) ≤ 0.05 were considered significant. The delta method was used to estimate the variance of the prevalence ratio (PR). A total of 141 patients (120 women and 21 men) with SSc were studied, including 33.3% with diffuse cutaneous SSc (dcSSc), 62.4% with limited cutaneous SSc (lcSSc), and 4.3% with sine scleroderma. Pulmonary fibrosis was present in 61 patients (43.3%), and the HLA-A∗30 and DQB1∗04 alleles were related to susceptibility. In contrast, the HLA-DRB1∗01 and DQB1∗05 alleles were protective. Pulmonary arterial hypertension was diagnosed in 19 patients (13.5%) and was associated with HLA-B∗35 and C∗04; in contrast, C∗03 seemed to be protective. Our current study documents the association of some classes I and II HLA alleles with the most severe clinical manifestations in a multiethnic case series. Our findings differed slightly from the previous data in other populations.en
dc.relation.ispartofDisease Markerspt_BR
dc.relation.ispartofabbreviationDis. Markerspt_BR
dc.identifier.citationDisease Markers. v. 35, n. 2, p. 73-8, 2013.pt_BR
dc.description.provenanceMade available in DSpace on 2015-11-27T13:32:16Z (GMT). No. of bitstreams: 1 pmed_24167351.pdf: 510498 bytes, checksum: f163256218711e1ddd3d75839b7589fa (MD5) Previous issue date: 2013en
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